M
Mikael C. I. Karlsson
Researcher at Karolinska Institutet
Publications - 100
Citations - 5171
Mikael C. I. Karlsson is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 31, co-authored 94 publications receiving 4168 citations. Previous affiliations of Mikael C. I. Karlsson include Rockefeller University & Karolinska University Hospital.
Papers
More filters
Journal ArticleDOI
Identification of a receptor required for the anti-inflammatory activity of IVIG
TL;DR: Sign-R1 has been shown to preferentially bind to 2,6-sialylated glycoproteins as discussed by the authors, which suggests that a specific binding site is created by the sialylation of IgG Fc.
Journal ArticleDOI
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Anna-Maria Georgoudaki,Kajsa E. Prokopec,Vanessa F. Boura,Eva Hellqvist,Silke Sohn,Jeanette Östling,Rony Dahan,Robert A. Harris,Mattias Rantalainen,Daniel Klevebring,Malin Sund,Suzanne Egyhazi Brage,Jonas Fuxe,Charlotte Rolny,Fubin Li,Fubin Li,Jeffrey V. Ravetch,Mikael C. I. Karlsson +17 more
TL;DR: It is found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome, and it is demonstrated that immunotherapies using antibodies designed to modify myeloid cells of the TME represent a promising mode of cancer treatment.
Journal ArticleDOI
Macrophages Control the Retention and Trafficking of B Lymphocytes in the Splenic Marginal Zone
Mikael C. I. Karlsson,Rodolphe Guinamard,Rodolphe Guinamard,Silvia Bolland,Silvia Bolland,Marko Sankala,Ralph M. Steinman,Jeffrey V. Ravetch +7 more
TL;DR: The MZMO phenotype was reverted in SHIP/Bruton's tyrosine kinase (Btk) double knockout mice, thus identifying the Btk activating pathway as an essential component being regulated by SHIP, and a direct interaction between the MARCO scavenger receptor on MZ MOs and MZBs was identified.
Journal ArticleDOI
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
M-F Pang,M-F Pang,A-M Georgoudaki,L. Lambut,Jonas Johansson,Vedrana Tabor,Kazuhiro Hagikura,Kazuhiro Hagikura,Yi Jin,Malin Jansson,J. S. Alexander,Celeste M. Nelson,Lars Jakobsson,Christer Betsholtz,Malin Sund,Mikael C. I. Karlsson,Jonas Fuxe +16 more
TL;DR: The results identify TGF-β1-induced EMT as a mechanism, which activates tumor cells for targeted, DC-like migration through the lymphatic system, and suggests that p38 MAP kinase inhibition may be a useful strategy to inhibit EMT and lymphogenic spread of tumor cells.
Journal ArticleDOI
Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism.
Khaleda Rahman Qazi,Ulf Gehrmann,Emilie Domange Jordö,Mikael C. I. Karlsson,Susanne Gabrielsson +4 more
TL;DR: It is found that B cells are needed for exosomal T-cell stimulation because Bruton tyrosine kinase-deficient mice showed abrogated B- and T- cell responses after OVA-Exo immunization.