F
Fubin Li
Researcher at Shanghai Jiao Tong University
Publications - 33
Citations - 3186
Fubin Li is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 15, co-authored 28 publications receiving 2575 citations. Previous affiliations of Fubin Li include City University of New York & Rockefeller University.
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Journal ArticleDOI
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R. Simpson,Fubin Li,Welby Montalvo-Ortiz,Manuel A. Sepulveda,Katharina Bergerhoff,Frederick Arce,Claire Roddie,Jake Y. Henry,Hideo Yagita,Jedd D. Wolchok,Karl S. Peggs,Jeffrey V. Ravetch,James P. Allison,Sergio A. Quezada +13 more
TL;DR: Anti–CTLA-4 antibody induces selective depletion of T reg cells within tumor lesions in a manner that is dependent on the presence of Fc gamma receptor-expressing macrophages within the tumor microenvironment.
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Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Anna-Maria Georgoudaki,Kajsa E. Prokopec,Vanessa F. Boura,Eva Hellqvist,Silke Sohn,Jeanette Östling,Rony Dahan,Robert A. Harris,Mattias Rantalainen,Daniel Klevebring,Malin Sund,Suzanne Egyhazi Brage,Jonas Fuxe,Charlotte Rolny,Fubin Li,Fubin Li,Jeffrey V. Ravetch,Mikael C. I. Karlsson +17 more
TL;DR: It is found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome, and it is demonstrated that immunotherapies using antibodies designed to modify myeloid cells of the TME represent a promising mode of cancer treatment.
Journal ArticleDOI
Inhibitory Fcγ Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies
Fubin Li,Jeffrey V. Ravetch +1 more
TL;DR: It is found that coengagement of the Fc domain of agonistic CD40 monoclonal antibodies (mAbs) with the inhibitory Fcγ receptor F cγRIIB is required for immune activation.
Journal ArticleDOI
Mouse model recapitulating human Fcγ receptor structural and functional diversity
TL;DR: These human FcγRs are shown to function to mediate the immunomodulatory, inflammatory, and cytotoxic activities of human IgG antibody and Fc engineered variants and provide a platform for the detailed mechanistic analysis of therapeutic and pathogenic IgG antibodies.
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Chromatin Architecture near a Potential 3′ End of the Igh Locus Involves Modular Regulation of Histone Modifications during B-Cell Development and In Vivo Occupancy at CTCF Sites
Francine E. Garrett,Alexander Emelyanov,Manuel A. Sepulveda,Patrick T. Flanagan,Sabrina A. Volpi,Fubin Li,Dmitry Loukinov,Laurel A. Eckhardt,Victor V. Lobanenkov,Barbara K. Birshtein +9 more
TL;DR: M measuring levels of acetylated histones H3 and H4 and of dimethylated H3 (K4) with chromatin immunoprecipitation assays suggest that 3′ RR elements are located within a specific chromatin subdomain that contains CTCF binding sites and developmentally regulated modules.