Z
Zhuo Chen
Researcher at Beckman Research Institute
Publications - 17
Citations - 1397
Zhuo Chen is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: Inflammation & Vascular smooth muscle. The author has an hindex of 12, co-authored 17 publications receiving 1092 citations. Previous affiliations of Zhuo Chen include City of Hope National Medical Center.
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Journal ArticleDOI
Evaluating the Role of Epigenetic histone modifications in the Metabolic Memory of Type 1 Diabetes.
Feng Miao,Zhuo Chen,Saul Genuth,Andrew D. Paterson,Lingxiao Zhang,Xiwei Wu,Sierra Min Li,Patricia A. Cleary,Arthur D. Riggs,David M. Harlan,Gayle M. Lorenzi,Orville G. Kolterman,Wanjie Sun,John M. Lachin,Rama Natarajan +14 more
TL;DR: Results suggest an association between HbA1c level and H3K9Ac, and a possible epigenetic explanation for metabolic memory in humans.
Journal ArticleDOI
An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy.
Mitsuo Kato,Mei Wang,Zhuo Chen,Kirti Bhatt,Hyung Jung Oh,Linda Lanting,Supriya Deshpande,Ye Jia,Jennifer Y. Lai,Christopher L. O’Connor,YiFan Wu,Jeffrey B. Hodgin,Robert G. Nelson,Markus Bitzer,Rama Natarajan +14 more
TL;DR: It is shown that a megacluster of nearly 40 microRNAs and their host long non-coding RNA transcript (lnc-MGC) are coordinately increased in the glomeruli of mouse models of DN, and mesangial cells treated with transforming growth factor-β1 (TGF- β1) or high glucose.
Journal ArticleDOI
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
Zhuo Chen,Feng Miao,Andrew D. Paterson,John M. Lachin,Lingxiao Zhang,Dustin E. Schones,Xiwei Wu,Jinhui Wang,Joshua D. Tompkins,Saul Genuth,Barbara H. Braffett,Arthur D. Riggs,Dcct,Rama Natarajan +13 more
TL;DR: Results show that DNA-me differences during the DCCT persist at certain loci associated with glycemia for several years during the EDIC Study and support an epigenetic explanation for metabolic memory.
Journal ArticleDOI
MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens†
Lihong Weng,Xiwei Wu,Hanlin Gao,Bing Mu,Xuejun Li,Jinhui Wang,Chao Guo,Jennifer M. Jin,Zhuo Chen,Maricela Covarrubias,Yate-Ching Yuan,Lawrence M. Weiss,Huiqing Wu +12 more
TL;DR: To the authors' knowledge, this is the first study to demonstrate that FFPE specimens can be used reliably for miRNA deep‐sequencing analysis, making future large‐scale clinical cohort/trial‐based studies possible.
Journal ArticleDOI
Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA
Marpadga A. Reddy,Zhuo Chen,Jung Tak Park,Mei Wang,Linda Lanting,Qiang Zhang,Kirti Bhatt,Amy Leung,Xiwei Wu,Sumanth Putta,Pål Sætrom,Sridevi Devaraj,Rama Natarajan +12 more
TL;DR: The diabetic macrophage transcriptome is defined and novel functional roles for lncRNAs in macrophages that could lead to lncRNA-based therapies for inflammatory diabetes complications are defined.