J
Jeffrey D. Dvorin
Researcher at Boston Children's Hospital
Publications - 41
Citations - 2144
Jeffrey D. Dvorin is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Plasmodium falciparum & Cytokinesis. The author has an hindex of 20, co-authored 35 publications receiving 1728 citations. Previous affiliations of Jeffrey D. Dvorin include Harvard University & University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes
Jeffrey D. Dvorin,Jeffrey D. Dvorin,Derek C. Martyn,Saurabh D. Patel,Saurabh D. Patel,Joshua S. Grimley,Christine R. Collins,Christine S. Hopp,A. Taylor Bright,Scott J. Westenberger,Elizabeth A. Winzeler,Elizabeth A. Winzeler,Michael J. Blackman,David A. Baker,Thomas J. Wandless,Manoj T. Duraisingh +15 more
TL;DR: It is found that the plant-like calcium-dependent protein kinase PfCDPK5, which is expressed in invasive merozoite forms of Plasmodium falciparum, was critical for egress from the human host erythrocyte, an essential step in the parasite life cycle.
Journal ArticleDOI
HIV-1 infection requires a functional integrase NLS.
Michèle Bouyac-Bertoia,Jeffrey D. Dvorin,Ron A. M. Fouchier,Ron A. M. Fouchier,Yonchu Jenkins,Barbara E. Meyer,Lily I. Wu,Michael Emerman,Michael H. Malim +8 more
TL;DR: It is suggested that interactions between uncoated viral nucleoprotein complexes and the host cell nuclear import machinery are critical for HIV-1 infection of all cells.
Journal ArticleDOI
Reassessment of the Roles of Integrase and the Central DNA Flap in Human Immunodeficiency Virus Type 1 Nuclear Import
Jeffrey D. Dvorin,Peter Bell,Gerd G. Maul,Masahiro Yamashita,Michael Emerman,Michael H. Malim +5 more
TL;DR: It is found that viruses with cPPT mutations still replicated productively in both dividing and nondividing cells, while viruses with a mutation at IN-V165 did not, and neither the cPPt nor the valine residue at position 165 of integrase is essential for the nuclear import of HIV-1 PICs.
Journal ArticleDOI
A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.
Andrew Farrell,Sivasakthivel Thirugnanam,Alexander Lorestani,Jeffrey D. Dvorin,Jeffrey D. Dvorin,Keith P. Eidell,David J. P. Ferguson,Brooke R. Anderson-White,Manoj T. Duraisingh,Gabor T. Marth,Marc-Jan Gubbels +10 more
TL;DR: The phenotype of a Toxoplasma gondii conditional mutant impaired in host cell invasion and egress was pinpointed to a defect in secretion of the micronemes, an apicomplexan-specific organelle that contains adhesion proteins.
Journal ArticleDOI
Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria.
Rose A. Lee,Rose A. Lee,Rose A. Lee,Helena de Puig,Helena de Puig,Peter Q. Nguyen,Nicolaas M. Angenent-Mari,Nicolaas M. Angenent-Mari,Nina M. Donghia,James P. McGee,Jeffrey D. Dvorin,Catherine M. Klapperich,Nira R. Pollock,Nira R. Pollock,James J. Collins,James J. Collins,James J. Collins +16 more
TL;DR: An integrated, 60-min, ultrasensitive and specific CRISPR-based diagnostic for the four major pathogenic Plasmodium species that can fill diagnostic gaps in asymptomatic carriers and nonfalciparum malaria species.