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Chia-Tien Chang
Researcher at National University of Singapore
Publications - 2
Citations - 661
Chia-Tien Chang is an academic researcher from National University of Singapore. The author has contributed to research in topics: Leukemia & Haematopoiesis. The author has an hindex of 2, co-authored 2 publications receiving 603 citations.
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Journal ArticleDOI
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.
King Pan Ng,Axel M. Hillmer,Charles Chuah,Charles Chuah,Wen Chun Juan,Tun Kiat Ko,Audrey S.M. Teo,Pramila N. Ariyaratne,Naoto Takahashi,Kenichi Sawada,Yao Fei,Yao Fei,Sheila Soh,Wah Heng Lee,John W.J. Huang,John Carson Allen,Xing Yi Woo,Niranjan Nagarajan,Vikrant Kumar,Anbupalam Thalamuthu,Wan Ting Poh,Ai Leen Ang,Hae Tha Mya,Gee Fung How,L.Y. Yang,Liang Piu Koh,Balram Chowbay,Chia-Tien Chang,V. S. Nadarajan,Wee Joo Chng,Hein Than,Lay Cheng Lim,Yeow Tee Goh,Shenli Zhang,Dianne Poh,Patrick Tan,Patrick Tan,Ju Ee Seet,Mei-Kim Ang,Noan-Minh Chau,Quan Sing Ng,Daniel Shao-Weng Tan,Manabu Soda,Kazutoshi Isobe,Markus M. Nöthen,Tien Yin Wong,Atif Shahab,Xiaoan Ruan,Valere Cacheux-Rataboul,Wing-Kin Sung,Eng Huat Tan,Yasushi Yatabe,Hiroyuki Mano,Hiroyuki Mano,Ross A. Soo,Tan Min Chin,Wan-Teck Lim,Yijun Ruan,Yijun Ruan,S. Tiong Ong +59 more
TL;DR: The results offer an explanation for the heterogeneity of TKI responses across individuals and suggest the possibility of personalizing therapy with BH3 mimetics to overcome BIM-polymorphism–associated TKI resistance.
Journal ArticleDOI
Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function
Sharon Xiaodai Lim,Tzuen Yih Saw,Min Zhang,Matthew R. Janes,Kassoum Nacro,Jeffrey Hill,An Qi Lim,Chia-Tien Chang,David A. Fruman,David A. Rizzieri,Soo Yong Tan,Hung Fan,Charles Chuah,Charles Chuah,S. Tiong Ong +14 more
TL;DR: This work shows that the MAP kinase interacting serine/threonine kinase (MNK)-eukaryotic translation initiation factor 4E (eIF4E) axis is overexpressed in BC GMPs but not normal HSCs, and suggests that pharmacologic inhibition of the MNK kinases may be therapeutically useful in BC chronic myeloid leukemia.