Jeffrey L. Evelhoch

TL;DR: Differences between ADR-sensitive and -resistant tumors for the changes observed 1 day after treatment (prior to significant decreases in tumor size) are evidence in support of the hypothesis that in vivo 31P-NMR provides response-specific markers of ADR sensitivity.

TL;DR: Investigating the effects of BUP dose and route of administration on central nervous system (CNS) pain circuitry demonstrated the potential of evoked pain fMRI and resting-state functional connectivity as objective tools that can inform the process of dose selection.

TL;DR: How functional imaging-derived information on activity in pain-processing brain regions could have predicted that NK-1RAs would have a low probability of success in this therapeutic domain is discussed.

TL;DR: This study demonstrates that the hemodynamic response to nociception is spatial-dependent, and the widespread activations in the brain in CBV fMRI are similar to what have been observed in C-2-deoxyglucose (2DG) autoradiography and PET; and the similarity of activation patterns suggests that nOCiceptive processing in rats is similar during NES and NMS.