J
James Dooley
Researcher at Katholieke Universiteit Leuven
Publications - 92
Citations - 6688
James Dooley is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Immune system & Cellular differentiation. The author has an hindex of 34, co-authored 81 publications receiving 5924 citations. Previous affiliations of James Dooley include Allen Institute for Brain Science & University of Washington.
Papers
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Journal ArticleDOI
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Jason D. Fontenot,Jeffrey P. Rasmussen,Luke M. Williams,James Dooley,Andrew G. Farr,Alexander Y. Rudensky +5 more
TL;DR: Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions, and it is shown that expression ofFoxp3 is highly restricted to the subset alphabeta of T cells and, irrespective of CD25 expression, correlates with suppressor activity.
Journal ArticleDOI
Developmental regulation of Foxp3 expression during ontogeny
TL;DR: It is demonstrated that the development of Foxp3-expressing T reg cells is substantially delayed relative to nonregulatory thymocytes during ontogeny, and it is speculated that induction ofFoxp3 in developingThymocytes and, thus, commitment to the T reg cell lineage is facilitated by a signal largely associated with the thymic medulla.
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Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome
Mira M. Wouters,Dafne Balemans,Sander Van Wanrooy,James Dooley,Vincent Cibert-Goton,Yeranddy A. Alpizar,Eduardo E. Valdez-Morales,Yasmin Nasser,Paul P. Van Veldhoven,Winde Vanbrabant,Schalk Van der Merwe,Raf Mols,Bart Ghesquière,Carla Cirillo,Inge Kortekaas,Peter Carmeliet,Willy Peetermans,Severine Vermeire,Paul Rutgeerts,Patrick Augustijns,Peter Hellings,Peter Hellings,Ann Belmans,Stephen J. Vanner,David C. Bulmer,Karel Talavera,Pieter Vanden Berghe,Adrian Liston,Guy E. Boeckxstaens +28 more
TL;DR: Ebastine, an antagonist of HRH1, reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS and inhibitors of this pathway might be developed as a new treatment approach for IBS.
Journal ArticleDOI
The cellular composition of the human immune system is shaped by age and cohabitation
Edward J. Carr,James Dooley,Josselyn E. Garcia-Perez,Vasiliki Lagou,James Lee,Carine Wouters,Isabelle Meyts,An Goris,Guy E. Boeckxstaens,Michelle A. Linterman,Adrian Liston +10 more
TL;DR: A high level of interindividual variation, with low longitudinal variation, at the level of cellular subset composition of the immune system, and local environmental conditions as a key factor in shaping the human immune system are identified.
Journal ArticleDOI
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
Seth L. Masters,Seth L. Masters,Vasiliki Lagou,Isabelle Jéru,Isabelle Jéru,Paul J. Baker,Paul J. Baker,Lien Van Eyck,David A. Parry,Dylan Lawless,Dominic De Nardo,Dominic De Nardo,Josselyn E. Garcia-Perez,Laura F. Dagley,Laura F. Dagley,Caroline L. Holley,James Dooley,Fiona Moghaddas,Fiona Moghaddas,Emanuela Pasciuto,Pierre-Yves Jeandel,Raf Sciot,Dena Lyras,Andrew I. Webb,Andrew I. Webb,Sandra E. Nicholson,Sandra E. Nicholson,Lien De Somer,Erika Van Nieuwenhove,Julia Ruuth-Praz,Bruno Copin,Emmanuelle Cochet,Myrna Medlej-Hashim,André Mégarbané,Kate Schroder,Sinisa Savic,An Goris,Serge Amselem,Serge Amselem,Carine Wouters,Adrian Liston +40 more
TL;DR: In this paper, a family with a dominantly inherited autoinflammatory disease, distinct from FMF, characterized by childhood-onset recurrent episodes of neutrophilic dermatosis, fever, elevated acute-phase reactants, arthralgia, and myalgia/myositis, was caused by a mutation in MEFV, the gene encoding pyrin (S242R).