A
Andrew G. Farr
Researcher at University of Washington
Publications - 123
Citations - 14063
Andrew G. Farr is an academic researcher from University of Washington. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 58, co-authored 123 publications receiving 13592 citations. Previous affiliations of Andrew G. Farr include Massachusetts Institute of Technology & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Jason D. Fontenot,Jeffrey P. Rasmussen,Luke M. Williams,James Dooley,Andrew G. Farr,Alexander Y. Rudensky +5 more
TL;DR: Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions, and it is shown that expression ofFoxp3 is highly restricted to the subset alphabeta of T cells and, irrespective of CD25 expression, correlates with suppressor activity.
Journal ArticleDOI
A mechanism for the initiation of allergen-induced T helper type 2 responses
TL;DR: It is shown that basophils were activated and recruited to the draining lymph nodes specifically in response to TH2–inducing allergen challenge, and it is demonstrated that the basophil was the accessory cell type required for TH2 induction in Response to protease allergens.
Journal ArticleDOI
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.
Terry Nakagawa,Wera Roth,Phillip Wong,Andrew Nelson,Andrew G. Farr,Jan M. Deussing,Jose A Villadangos,Hidde L. Ploegh,Christoph Peters,Alexander Y. Rudensky +9 more
TL;DR: The identification of a protease involved in class II presentation in a tissue-specific manner suggests a potential means of manipulating CD4+ T cell responsiveness in vivo.
Journal ArticleDOI
T cell receptor δ gene mutant mice : independent generation of αβ T cells and programmed rearrangements of γδ TCR genes
Shigeyoshi Itohara,Peter Mombaerts,Juan J. Lafaille,John Iacomini,Andrew J. Nelson,Alan Richard Clarke,Martin L. Hooper,Andrew G. Farr,Susumu Tonegawa +8 more
TL;DR: The analyses of TCR γ and δ genes in the mutant mice suggest that intracellular mechanisms acting at the level of DNA rearrangement play key roles in the differential δ and γ gene rearrangements and in the generation of the highly restricted junctional sequences during fetal thymic development.
Journal ArticleDOI
Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia
Shigeyoshi Itohara,Shigeyoshi Itohara,Shigeyoshi Itohara,Andrew G. Farr,Andrew G. Farr,Andrew G. Farr,Juan J. Lafaille,Juan J. Lafaille,Juan J. Lafaille,Marc Bonneville,Marc Bonneville,Marc Bonneville,Yohtaroh Takagaki,Yohtaroh Takagaki,Yohtaroh Takagaki,Werner Haas,Werner Haas,Werner Haas,Susumu Tonegawa,Susumu Tonegawa,Susumu Tonegawa +20 more
TL;DR: A second homogeneous γδ T-cell subset is revealed in epithelia not of the intestine and skin, but of the vagina, uterus and tongue, which seems to originate from early fetal thymocytes.