J
Jeffrey S. Hrkach
Researcher at Massachusetts Institute of Technology
Publications - 49
Citations - 5055
Jeffrey S. Hrkach is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Polymerization & Biodegradable polymer. The author has an hindex of 28, co-authored 49 publications receiving 4864 citations. Previous affiliations of Jeffrey S. Hrkach include Carnegie Mellon University & University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Large Porous Particles for Pulmonary Drug Delivery
David A. Edwards,Justin Hanes,Giovanni Caponetti,Jeffrey S. Hrkach,Abdellaziz Ben-Jebria,Mary Lou Eskew,Jeffrey Mintzes,Daniel R. Deaver,Noah Lotan,Robert Langer +9 more
TL;DR: A new type of inhalation aerosol, characterized by particles of small mass density and large size, permitted the highly efficient delivery of inhaled therapeutics into the systemic circulation.
Journal ArticleDOI
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
Jeffrey S. Hrkach,Daniel D. Von Hoff,Mir Mukkaram Ali,Elizaveta Andrianova,Jason Auer,Tarikh Christopher Campbell,David De Witt,Michael Figa,Maria Figueiredo,Allen Horhota,Susan Low,Kevin McDonnell,Erick Peeke,Beadle Retnarajan,Abhimanyu Sabnis,Edward Schnipper,Jeffrey J. Song,Young-Ho Song,Jason Summa,Douglas Tompsett,Greg Troiano,Tina Van Geen Hoven,James Wright,Patricia LoRusso,Philip W. Kantoff,Neil H. Bander,Christopher Sweeney,Omid C. Farokhzad,Robert Langer,Stephen E. Zale +29 more
TL;DR: Developing and clinical translation of a targeted polymeric nanoparticle (TNP) containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with solid tumors and initial clinical data indicated that DTXL-TNP displays a pharmacological profile differentiated from sb-DTXL.
Patent
Aerodynamically light particles for pulmonary drug delivery
David A. Edwards,Giovannia Caponetti,Jeffrey S. Hrkach,Noah Lotan,Justin Hanes,Abdell Aziz Ben-Jebria,Robert Langer +6 more
TL;DR: Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided in this paper, where the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 µm and 30 µm.
Journal ArticleDOI
Bacterial inactivation by using near- and supercritical carbon dioxide
TL;DR: A potential new method of sterilization is demonstrated by using supercritical fluid carbon dioxide to achieve complete inactivation of a wide variety of bacterial organisms at moderate temperatures and in the absence of organic solvents or irradiation.
Journal ArticleDOI
Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial.
Alonzo D. Cook,Jeffrey S. Hrkach,Nicholas N. Gao,Ivette M. Johnson,Utpal B. Pajvani,Scott M. Cannizzaro,Robert Langer +6 more
TL;DR: The significance of this work is that the first synthetic interactive, resorbable biomaterial has been developed, and use of this material to control cell behavior has been demonstrated.