G
Greg Troiano
Researcher at Pfizer
Publications - 49
Citations - 2803
Greg Troiano is an academic researcher from Pfizer. The author has contributed to research in topics: Nanoparticle & Electroporation. The author has an hindex of 23, co-authored 49 publications receiving 2545 citations. Previous affiliations of Greg Troiano include Johns Hopkins University & Vassar College.
Papers
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Journal ArticleDOI
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
Jeffrey S. Hrkach,Daniel D. Von Hoff,Mir Mukkaram Ali,Elizaveta Andrianova,Jason Auer,Tarikh Christopher Campbell,David De Witt,Michael Figa,Maria Figueiredo,Allen Horhota,Susan Low,Kevin McDonnell,Erick Peeke,Beadle Retnarajan,Abhimanyu Sabnis,Edward Schnipper,Jeffrey J. Song,Young-Ho Song,Jason Summa,Douglas Tompsett,Greg Troiano,Tina Van Geen Hoven,James Wright,Patricia LoRusso,Philip W. Kantoff,Neil H. Bander,Christopher Sweeney,Omid C. Farokhzad,Robert Langer,Stephen E. Zale +29 more
TL;DR: Developing and clinical translation of a targeted polymeric nanoparticle (TNP) containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with solid tumors and initial clinical data indicated that DTXL-TNP displays a pharmacological profile differentiated from sb-DTXL.
Patent
Drug loaded polymeric nanoparticles and methods of making and using same
TL;DR: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol as mentioned in this paper.
Journal ArticleDOI
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo
Susan Ashton,Young-Ho Song,Jim Nolan,Elaine Cadogan,Jim Murray,Rajesh Odedra,John R. Foster,Peter A. Hall,Susan Low,Paula Taylor,Rebecca Ellston,Urszula M. Polanska,Joanne Wilson,Colin Howes,Aaron Smith,Richard J. A. Goodwin,John G. Swales,Nicole Strittmatter,Zoltan Takats,Anna Nilsson,Per E. Andrén,Dawn Trueman,Michael A. Walker,Corinne Reimer,Greg Troiano,Donald Parsons,David De Witt,Marianne Ashford,Jeff Hrkach,Stephen E. Zale,Philip J. Jewsbury,Simon T. Barry +31 more
TL;DR: It is demonstrated that AZD2811 can be formulated in nanoparticles using ion pairing agents to give improved efficacy and tolerability in preclinical models with less frequent dosing and can increase the therapeutic index of molecularly targeted agents, including kinase inhibitors targeting cell cycle and oncogenic signal transduction pathways.
Journal ArticleDOI
Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona.
John E. Blume,William C. Manning,Greg Troiano,Daniel Hornburg,Michael Figa,Lyndal K. Hesterberg,Theodore L. Platt,Xiaoyan Zhao,Rea A. Cuaresma,Patrick A. Everley,Marwin Ko,Hope Liou,Max Mahoney,Shadi Ferdosi,Eltaher M. Elgierari,Stolarczyk Craig,Behzad Tangeysh,Hongwei Xia,Ryan W. Benz,Asim Siddiqui,Steven A. Carr,Philip Ma,Robert Langer,Vivek F. Farias,Omid C. Farokhzad +24 more
TL;DR: A highly parallel protein quantitation platform integrating nanoparticle (NP) protein coronas with liquid chromatography-mass spectrometry for efficient proteomic profiling and biomarker discovery is developed.
Journal ArticleDOI
The Reduction in Electroporation Voltages by the Addition of a Surfactant to Planar Lipid Bilayers
TL;DR: It is suggested that C12E8 incorporates into POPC bilayers, allowing electroporation at lower intensities and/or shorter durations, and it is demonstrated that surfactants can be used to manipulate the Electroporation threshold of lipid bilayers.