Kevin McDonnell

TL;DR: Developing and clinical translation of a targeted polymeric nanoparticle (TNP) containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with solid tumors and initial clinical data indicated that DTXL-TNP displays a pharmacological profile differentiated from sb-DTXL.

TL;DR: The results provide a coherent illustration of the ability of controllable‐release PLA‐PEG nanoparticles to serve as an effective drug delivery platform to alter API biodistribution and underscore the importance of physiological effects of released drug in determining the biodist distribution of therapeutic drug formulations at doses approaching tolerability limits.

TL;DR: The data demonstrate the utility of radioimaging to assess nanoparticle biodistribution and suggest that active targeting has a modest positive effect on tumor localization of PSMA-targeted PLA-PEG nanoparticles that have been derivatized for imaging.

TL;DR: It is shown that several 4-cyclohexylamino analogues have potent binding affinity for CD38 using surface plasmon resonance and active amine analogues could be acylated and functionalized with alkyne and fluorescein groups.