J
Jenni Harvey
Researcher at University of Dundee
Publications - 59
Citations - 3875
Jenni Harvey is an academic researcher from University of Dundee. The author has contributed to research in topics: Leptin & Synaptic plasticity. The author has an hindex of 31, co-authored 56 publications receiving 3269 citations. Previous affiliations of Jenni Harvey include University of Nevada, Reno.
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Journal ArticleDOI
Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity
TL;DR: Data indicate that a novel action of leptin in the CNS is to facilitate hippocampal synaptic plasticity via enhanced NMDA receptor-mediated Ca(2+) influx.
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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Stephen C. Cunnane,Eugenia Trushina,Cecilie Morland,Alessandro Prigione,Gemma Casadesus,Zane B. Andrews,M. Flint Beal,Linda H. Bergersen,Roberta Diaz Brinton,Suzanne M. de la Monte,Anne Eckert,Jenni Harvey,Ross Jeggo,Jack H. Jhamandas,Oliver Kann,Clotilde Mannoury la Cour,William Martin,Gilles Mithieux,Paula I. Moreira,Michael P. Murphy,Klaus-Armin Nave,Tal Nuriel,Stéphane H. R. Oliet,Stéphane H. R. Oliet,Frédéric Saudou,Frédéric Saudou,Mark P. Mattson,Russell H. Swerdlow,Millan Mark +28 more
TL;DR: The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.
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Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees
Mary J. Palmer,Christopher Moffat,Nastja Saranzewa,Jenni Harvey,Geraldine A. Wright,Christopher N. Connolly +5 more
TL;DR: These findings demonstrate a neuronal mechanism that may account for the cognitive impairments caused by neonicotinoids, and predict that exposure to multiple pesticides that target cholinergic signalling will cause enhanced toxicity to pollinators.
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Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.
TL;DR: Data indicate that leptin, via PI 3‐kinase‐driven activation of BK channels, elicits a novel mechanism for controlling neuronal excitability in the hippocampus, which could provide an alternative therapeutic target in the management of epilepsy.
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Leptin regulation of neuronal excitability and cognitive function
TL;DR: Characterisation of these novel actions of leptin is providing valuable insights into the role of this hormone in the regulation of diverse neuronal functions in health and disease.