J
Jennifer L. Endres
Researcher at University of Nebraska Medical Center
Publications - 25
Citations - 2690
Jennifer L. Endres is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Biofilm & Mutant. The author has an hindex of 12, co-authored 23 publications receiving 2253 citations.
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Journal ArticleDOI
A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes
Paul D. Fey,Jennifer L. Endres,Vijaya Kumar Yajjala,Todd J. Widhelm,Robert Boissy,Jeffrey L. Bose,Kenneth W. Bayles +6 more
TL;DR: A sequence-defined transposon mutant library consisting of 1,952 strains, each containing a single mutation within a nonessential gene of the epidemic community-associated methicillin-resistant S. aureus (CA-MRSA) strain repository is generated.
Journal ArticleDOI
The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus.
Kelly C. Rice,Ethan E. Mann,Jennifer L. Endres,Elizabeth C. Weiss,James E. Cassat,Mark S. Smeltzer,Kenneth W. Bayles +6 more
TL;DR: It is demonstrated that cidA-controlled cell lysis plays a significant role during biofilm development and that released genomic DNA is an important structural component of S. aureus biofilm.
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Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation.
Ethan E. Mann,Kelly C. Rice,Blaise R. Boles,Jennifer L. Endres,Dev K. Ranjit,Lakshimi Chandramohan,Laura H. Tsang,Mark S. Smeltzer,Alexander R. Horswill,Kenneth W. Bayles +9 more
TL;DR: A model in which the opposing activities of the cid and lrg gene products control cell lysis and genomic DNA release during biofilm development, while staphylococcal thermonuclease functions to degrade the eDNA, possibly as a means to promote biofilm dispersal is suggested.
Journal ArticleDOI
Predicting the virulence of MRSA from its genome sequence
Maisem Laabei,Mario Recker,Justine K. Rudkin,Mona Aldeljawi,Zeynep Gülay,Tim J. Sloan,Paul Williams,Jennifer L. Endres,Kenneth W. Bayles,Paul D. Fey,Vijaya Kumar Yajjala,Todd J. Widhelm,Erica Hawkins,Katie Lewis,Sara Parfett,Lucy Scowen,Sharon J. Peacock,Matthew T. G. Holden,Daniel J. Wilson,Timothy D. Read,Jean M. H. van den Elsen,Nicholas K. Priest,Edward J. Feil,Laurence D. Hurst,Elisabet Josefsson,Ruth C. Massey +25 more
TL;DR: Assayed the toxicity and adhesion of 90 MRSA (methicillin resistant S. aureus) isolates and found that while there was remarkably little variation in adhesion, toxicity varied by over an order of magnitude between isolates, suggesting different evolutionary selection pressures acting on these two traits.
Journal ArticleDOI
Staphylococcus aureus CidA and LrgA Proteins Exhibit Holin-Like Properties
TL;DR: The model that CidA and LrgA proteins are bacterial holin-/antiholin-like proteins that function to control cell death and lysis during biofilm development is supported.