J
Jean M. H. van den Elsen
Researcher at University of Bath
Publications - 69
Citations - 3445
Jean M. H. van den Elsen is an academic researcher from University of Bath. The author has contributed to research in topics: Complement system & Boronic acid. The author has an hindex of 28, co-authored 65 publications receiving 3076 citations. Previous affiliations of Jean M. H. van den Elsen include Utrecht University & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Exploiting the Reversible Covalent Bonding of Boronic Acids: Recognition, Sensing, and Assembly
Steven D. Bull,Matthew G. Davidson,Jean M. H. van den Elsen,John S. Fossey,A. Toby A. Jenkins,Yun-Bao Jiang,Yuji Kubo,Frank Marken,Kazuo Sakurai,Jianzhang Zhao,Tony D. James +10 more
TL;DR: The dynamic covalent functionality of boronic acids with structure-directing potential has led researchers to develop a variety of self-organizing systems including macrocycles, cages, capsules, and polymers.
Journal ArticleDOI
Correction: Corrigendum: Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer’s Disease
Omar Kassaar,Marta P. Pereira Morais,Su-Ying Xu,Emily L. Adam,Rosemary C. Chamberlain,Bryony Jenkins,Tony D. James,Paul T. Francis,Stephen A. Ward,Robert J. Williams,Jean M. H. van den Elsen +10 more
TL;DR: This paper presents a meta-analyses of the determinants of infectious disease in eight operation rooms and shows clear patterns of diarrhoea and vomiting in men and women diagnosed with central giant cell granuloma.
Journal ArticleDOI
Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure.
Barend Bouma,Philip G. de Groot,Jean M. H. van den Elsen,Raimond B. G. Ravelli,Arie Schouten,Marleen J. A. Simmelink,Ronald H. W. M. Derksen,Jan Kroon,Piet Gros +8 more
TL;DR: The observed spatial arrangement of the five domains suggests a functional partitioning of protein adhesion and membrane adhesion over the N‐ and C‐terminal domains, respectively, separated by glycosylated bridging domains.
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Predicting the virulence of MRSA from its genome sequence
Maisem Laabei,Mario Recker,Justine K. Rudkin,Mona Aldeljawi,Zeynep Gülay,Tim J. Sloan,Paul Williams,Jennifer L. Endres,Kenneth W. Bayles,Paul D. Fey,Vijaya Kumar Yajjala,Todd J. Widhelm,Erica Hawkins,Katie Lewis,Sara Parfett,Lucy Scowen,Sharon J. Peacock,Matthew T. G. Holden,Daniel J. Wilson,Timothy D. Read,Jean M. H. van den Elsen,Nicholas K. Priest,Edward J. Feil,Laurence D. Hurst,Elisabet Josefsson,Ruth C. Massey +25 more
TL;DR: Assayed the toxicity and adhesion of 90 MRSA (methicillin resistant S. aureus) isolates and found that while there was remarkably little variation in adhesion, toxicity varied by over an order of magnitude between isolates, suggesting different evolutionary selection pressures acting on these two traits.
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Structure of Golgi α-mannosidase II: A target for inhibition of growth and metastasis of cancer cells
TL;DR: The crystal structure of Drosophila Golgi α‐mannosidase II in the absence and presence of the anti‐cancer agent swainsonine and the inhibitor deoxymannojirimycin reveals a novel protein fold with an active site zinc intricately involved both in the substrate specificity of the enzyme and directly in the catalytic mechanism.