J
Jennifer L. McKimm-Breschkin
Researcher at Commonwealth Scientific and Industrial Research Organisation
Publications - 64
Citations - 6422
Jennifer L. McKimm-Breschkin is an academic researcher from Commonwealth Scientific and Industrial Research Organisation. The author has contributed to research in topics: Neuraminidase & Zanamivir. The author has an hindex of 35, co-authored 64 publications receiving 5975 citations. Previous affiliations of Jennifer L. McKimm-Breschkin include RMIT University & University of Melbourne.
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Journal ArticleDOI
ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
Hamsa Puthalakath,Lorraine A. O'Reilly,Priscilla Gunn,Lily Lee,P N Kelly,P N Kelly,Nicholas D. Huntington,Peter Hughes,Peter Hughes,Ewa M. Michalak,Jennifer L. McKimm-Breschkin,Noburo Motoyama,Tomomi Gotoh,Shizuo Akira,Philippe Bouillet,Andreas Strasser +15 more
TL;DR: It is found that Bim is essential for ER stress-induced apoptosis in a diverse range of cell types both in culture and within the whole animal.
Journal ArticleDOI
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor
Joseph N. Varghese,Jennifer L. McKimm-Breschkin,James B. Caldwell,Alexander A. Kortt,Peter M. Colman +4 more
TL;DR: Crystallographic studies of neuraminidase–sialic acid complexes indicate that sialic Acid is distorted on binding the enzyme, and three arginine residues on the enzyme interact with the carboxylate group of the sugar.
Journal ArticleDOI
Resistance of influenza viruses to neuraminidase inhibitors--a review.
TL;DR: In this paper, the authors identified key residues conserved across all HA subtypes, which are involved in receptor binding, including residues 134-138 and 224-228, on the right side of the ligand binding site, and residues 224−228 on the left side.
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Detection of Influenza Viruses Resistant to Neuraminidase Inhibitors in Global Surveillance during the First 3 Years of Their Use
Arnold S. Monto,Jennifer L. McKimm-Breschkin,Catherine A. Macken,Alan W. Hampson,Alan J. Hay,Alexander Klimov,Masato Tashiro,Robert G. Webster,Michelle Aymard,Frederick G. Hayden,Maria Zambon +10 more
TL;DR: The frequency of variants with decreased sensitivity to the NAIs did not increase significantly during this period, but continued surveillance is required, especially in regions with higher NAI use.
Journal ArticleDOI
Neuraminidase Sequence Analysis and Susceptibilities of Influenza Virus Clinical Isolates to Zanamivir and Oseltamivir
Jennifer L. McKimm-Breschkin,T. Trivedi,Alan W. Hampson,A. Hay,Alexander Klimov,Masato Tashiro,Frederick G. Hayden,Maria Zambon +7 more
TL;DR: The baseline susceptibilities prior to and shortly after the introduction of the NA inhibitors are established and there was no evidence of naturally occurring resistance to either drug in any of the isolates.