J
Jennifer P Habashi
Researcher at Johns Hopkins University School of Medicine
Publications - 30
Citations - 4916
Jennifer P Habashi is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Marfan syndrome & Aortic aneurysm. The author has an hindex of 15, co-authored 30 publications receiving 4432 citations. Previous affiliations of Jennifer P Habashi include Johns Hopkins University.
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Journal ArticleDOI
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Jennifer P Habashi,Daniel P. Judge,Tammy M. Holm,Ronald D. Cohn,Bart Loeys,Timothy K. Cooper,Loretha Myers,Erin C Klein,Guosheng Liu,Carla L. Calvi,Megan Podowski,Enid Neptune,Marc K. Halushka,Djahida Bedja,Kathleen L. Gabrielson,Daniel B. Rifkin,Luca Carta,Francesco Ramirez,David L. Huso,Harry C. Dietz +19 more
TL;DR: Losartan, a drug already in clinical use for hypertension, merits investigation as a therapeutic strategy for patients with Marfan syndrome and has the potential to prevent the major life-threatening manifestation of this disorder.
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Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome
Benjamin S. Brooke,Jennifer P Habashi,Daniel P. Judge,Nishant D. Patel,Bart Loeys,Bart Loeys,Harry C. Dietz +6 more
TL;DR: In a small cohort study, the use of ARB therapy in patients with Marfan's syndrome significantly slowed the rate of progressive aortic-root dilation.
Journal ArticleDOI
Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states
Ronald D. Cohn,Christel Van Erp,Jennifer P Habashi,Arshia Soleimani,Erin C Klein,Matthew T Lisi,Matthew Gamradt,Colette M. Ap Rhys,Tammy M. Holm,Bart Loeys,Francesco Ramirez,Daniel P. Judge,Christopher W. Ward,Harry C. Dietz +13 more
TL;DR: It is shown that increased TGF-β activity leads to failed muscle regeneration in fibrillin-1–deficient mice and a similar therapeutic response in a dystrophin-deficient mouse model of Duchenne muscular dystrophy.
Journal ArticleDOI
Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice
Tammy M. Holm,Jennifer P Habashi,Jefferson J. Doyle,Djahida Bedja,Yichun Chen,Christel Van Erp,Mark E. Lindsay,David Kim,Florian Schoenhoff,Ronald D. Cohn,Bart Loeys,Craig J. Thomas,Samarjit Patnaik,Juan J. Marugan,Daniel P. Judge,Harry C. Dietz +15 more
TL;DR: Noncanonical (Smad-independent) TGFβ signaling is a prominent driver of aortic disease in MFS mice, and inhibition of the ERK1/2 or JNK1 pathways is a potential therapeutic strategy for the disease.
Journal ArticleDOI
Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism
Jennifer P Habashi,Jefferson J. Doyle,Tammy M. Holm,Hamza Aziz,Florian Schoenhoff,Djahida Bedja,Yichun Chen,Alexandra N. Modiri,Daniel P. Judge,Harry C. Dietz +9 more
TL;DR: It is shown that loss of AT2 expression accelerates the aberrant growth and rupture of the aorta in a mouse model of Marfan syndrome, and losartan uniquely inhibited TGFβ-mediated activation of extracellular signal–regulated kinase (ERK), by allowing continued signaling through AT2.