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Carla L. Calvi
Researcher at Vanderbilt University Medical Center
Publications - 20
Citations - 2554
Carla L. Calvi is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Lung & Biology. The author has an hindex of 10, co-authored 11 publications receiving 1993 citations. Previous affiliations of Carla L. Calvi include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome.
Jennifer P Habashi,Daniel P. Judge,Tammy M. Holm,Ronald D. Cohn,Bart Loeys,Timothy K. Cooper,Loretha Myers,Erin C Klein,Guosheng Liu,Carla L. Calvi,Megan Podowski,Enid Neptune,Marc K. Halushka,Djahida Bedja,Kathleen L. Gabrielson,Daniel B. Rifkin,Luca Carta,Francesco Ramirez,David L. Huso,Harry C. Dietz +19 more
TL;DR: Losartan, a drug already in clinical use for hypertension, merits investigation as a therapeutic strategy for patients with Marfan syndrome and has the potential to prevent the major life-threatening manifestation of this disorder.
Journal ArticleDOI
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Arun C. Habermann,Austin J. Gutierrez,Linh T. Bui,Stephanie L. Yahn,Nichelle I. Winters,Carla L. Calvi,Lance M. Peter,Mei-I Chung,Chase J. Taylor,Christopher S. Jetter,Latha Raju,Jamie Roberson,Guixiao Ding,Lori Wood,Jennifer M.S. Sucre,Bradley W. Richmond,Bradley W. Richmond,Ana P. Serezani,Wyatt J. McDonnell,Simon B. Mallal,Simon B. Mallal,Matthew J. Bacchetta,James E. Loyd,Ciara M. Shaver,Lorraine B. Ware,Ross M. Bremner,Rajat Walia,Timothy S. Blackwell,Timothy S. Blackwell,Timothy S. Blackwell,Nicholas E. Banovich,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski +33 more
TL;DR: It is reported that a remarkable shift in epithelial cell phenotypes occurs in the peripheral lung in PF and several previously unrecognized epithelialcell phenotypes are identified, including a KRT5−/KRT17+ pathologic, ECM-producing epithel cell population that was highly enriched in PF lungs.
Posted ContentDOI
Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Arun C. Habermann,Austin J. Gutierrez,Linh T. Bui,Stephanie L. Yahn,Nichelle I. Winters,Carla L. Calvi,Lance M. Peter,Mei-I Chung,Chase J. Taylor,Christopher S. Jetter,Latha Raju,Jamie Roberson,Guixiao Ding,Lori Wood,Jennifer M.S. Sucre,Bradley W. Richmond,Bradley W. Richmond,Ana P. Serezani,Wyatt J. McDonnell,Simon B. Mallal,Simon B. Mallal,Matthew J. Bacchetta,James E. Loyd,Ciara M. Shaver,Lorraine B. Ware,Lorraine B. Ware,Ross M. Bremner,Rajat Walia,Timothy S. Blackwell,Timothy S. Blackwell,Timothy S. Blackwell,Nicholas E. Banovich,Jonathan A. Kropski,Jonathan A. Kropski,Jonathan A. Kropski +34 more
TL;DR: A remarkable shift in epithelial cell phenotypes occurs in the peripheral lung in PF, and several previously unrecognized epithelialcell phenotypes are identified including a KRT5−/KRT17+, pathologic ECM-producing epithel cell population that was highly enriched in PF lungs.
Journal ArticleDOI
Angiotensin receptor blockade attenuates cigarette smoke–induced lung injury and rescues lung architecture in mice
Megan Podowski,Carla L. Calvi,Shana Metzger,Kaori Misono,Hataya Poonyagariyagorn,Armando Lopez-Mercado,Therese Ku,Thomas Lauer,Sharon A. McGrath-Morrow,Alan E. Berger,Christopher Cheadle,Rubin M. Tuder,Rubin M. Tuder,Harry C. Dietz,Wayne Mitzner,Robert A. Wise,Enid Neptune +16 more
TL;DR: Data support the hypothesis that inhibition of TGF-β signaling through angiotensin receptor blockade can attenuate CS-induced lung injury in an established murine model, and provide a preclinical platform for the development of other T GF-β-targeted therapies for patients with COPD.
Journal ArticleDOI
Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung.
Carla L. Calvi,Megan Podowski,Armando Lopez-Mercado,Shana Metzger,Kaori Misono,Alla Malinina,Dustin Dikeman,Hataya Poonyagariyon,Leslie Ynalvez,Roshanak Derakhshandeh,Anne Le,Mark Merchant,Ralph H. Schwall,Enid Neptune +13 more
TL;DR: HGF signaling is necessary for alveolar homeostasis in the developing lung and that augmentation of HGF signaling can improve airspace morphology in murine emphysema, and studies converge on prosurvival signaling and antioxidant protection as critical pathways in HGF–mediated airspace maintenance or repair.