J
Jennifer Soto
Researcher at University of California, Los Angeles
Publications - 17
Citations - 629
Jennifer Soto is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Reprogramming & Medicine. The author has an hindex of 6, co-authored 12 publications receiving 447 citations. Previous affiliations of Jennifer Soto include University of California, Berkeley.
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Journal ArticleDOI
Biophysical regulation of epigenetic state and cell reprogramming
Timothy L. Downing,Jennifer Soto,Constant Morez,Constant Morez,Timothee Houssin,Timothee Houssin,Ashley L. Fritz,Falei Yuan,Falei Yuan,Julia Chu,Shyam Patel,David V. Schaffer,Song Li +12 more
TL;DR: It is shown that biophysical cues, in the form of parallel microgrooves on the surface of cell-adhesive substrates, can replace the effects of small-molecule epigenetic modifiers and significantly improve reprogramming efficiency and promote a mesenchymal-to-epithelial transition in adult fibroblasts.
Journal ArticleDOI
Adipocytes as Anticancer Drug Delivery Depot
Di Wen,Di Wen,Jinqiang Wang,Jinqiang Wang,George Van Den Driessche,Qian Chen,Qian Chen,Yuqi Zhang,Yuqi Zhang,Guojun Chen,Guojun Chen,Hongjun Li,Jennifer Soto,Ming Liu,Masao Ohashi,Zejun Wang,Peter Abdou,Quanyin Hu,Quanyin Hu,Gianpietro Dotti,Song Li,Denis Fourches,Zhen Gu,Zhen Gu +23 more
TL;DR: The lipid metabolism is exploited to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site, promoting antitumor efficacy and downregulation of PD-L1 expression is observed in tumor cells.
Journal ArticleDOI
Cell engineering: Biophysical regulation of the nucleus.
TL;DR: This review will highlight the recent progress in nuclear biomechanics and mechanobiology in the context of cell engineering, tissue remodeling and disease development.
Journal ArticleDOI
Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming
Jun Fang,Yuan Yu Hsueh,Yuan Yu Hsueh,Jennifer Soto,Wujin Sun,Jinqiang Wang,Zhen Gu,Ali Khademhosseini,Song Li +8 more
TL;DR: An overview of the state-of-the-art technologies for cell reprograming is presented and the recent breakthroughs in engineering biomaterials with micro/nanotechnologies to improve reprogramming efficiency and quality are highlighted.
Journal ArticleDOI
Biophysical regulation of cell reprogramming.
TL;DR: The recent advances in the use of biomaterials for iPS cell reprograming and direct reprogramming are reviewed, with a focus on the biophysical aspect, and the future challenges and directions of the field are highlighted.