J
Jeremy A. Squire
Researcher at University of São Paulo
Publications - 349
Citations - 41173
Jeremy A. Squire is an academic researcher from University of São Paulo. The author has contributed to research in topics: Comparative genomic hybridization & Fluorescence in situ hybridization. The author has an hindex of 87, co-authored 344 publications receiving 38764 citations. Previous affiliations of Jeremy A. Squire include University of Toronto & Kingston General Hospital.
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Journal ArticleDOI
In prostate cancer needle biopsies, detections of PTEN loss by fluorescence in situ hybridization (FISH) and by immunohistochemistry (IHC) are concordant and show consistent association with upgrading
Clarissa Gondim Picanço-Albuquerque,Carlos L. Morais,Filipe L.F. Carvalho,Sarah B. Peskoe,Jessica L. Hicks,Olga Ludkovski,Thiago Vidotto,Helen L. Fedor,Elizabeth B. Humphreys,Misop Han,Elizabeth A. Platz,Elizabeth A. Platz,A. M. De Marzo,David M. Berman,David M. Berman,Tamara L. Lotan,Jeremy A. Squire +16 more
TL;DR: FISH provides a different approach to determining PTEN loss when IHC is uncertain, and both FISH and IHC are concordant, showing consistent positive associations betweenPTEN loss and upgrading.
Journal ArticleDOI
Use of whole genome amplification and comparative genomic hybridisation to detect chromosomal copy number alterations in cell line material and tumour tissue.
TL;DR: The combination of amplification and gaCGH using DNA extracted from archival patient material has the potential for permitting the studying of DNA from small cancerous or pre-cancerous foci, which may help to identify potential genomic markers for early diagnosis.
Journal ArticleDOI
Sister Chromatid Exchange
Jane Bayani,Jeremy A. Squire +1 more
TL;DR: Differential staining with Hoechst dye and Giemsa allows the newly synthesized DNA within a chromatid to be recognized, since BrdU incorporation results in much weaker staining.
Journal ArticleDOI
Variant translocations of chromosome 22 in Ewing's sarcoma.
Jeremy A. Squire,Maria Zielenska,Paul S. Thorner,Shan Tennyson,Sheila Weitzman,K. Mohan Pai,Herman Yeger,Y-Kwan Ng,Rosanna Weksberg +8 more
TL;DR: Two new variant translocations are reported, both of which involve chromosomal rearrangements of 22q12, providing additional cytogenetic evidence that the sequences on chromosome 22 are critical.
Journal ArticleDOI
De novo 1q32q44 duplication and distal 1q trisomy syndrome
Małgorzata J.M. Nowaczyk,Jane Bayani,Viola C. P. Freeman,Viola C. P. Freeman,John Watts,Jeremy A. Squire,Jie Xu,Jie Xu +7 more
TL;DR: This is the sixth case of known duplication involving the 1q32q44 segment and the physical findings are similar to those of other patients reported previously, providing further evidence of the existence of the “distal 1q trisomy” phenotype.