J
Jeremy A. Squire
Researcher at University of São Paulo
Publications - 349
Citations - 41173
Jeremy A. Squire is an academic researcher from University of São Paulo. The author has contributed to research in topics: Comparative genomic hybridization & Fluorescence in situ hybridization. The author has an hindex of 87, co-authored 344 publications receiving 38764 citations. Previous affiliations of Jeremy A. Squire include University of Toronto & Kingston General Hospital.
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Journal ArticleDOI
The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases
Tamer Abou Youssif,Mona Fahmy,Ismaël Hervé Koumakpayi,Fernanda R. R. Ayala,Saeeda Al Marzooqi,Guangyong Chen,Pheroze Tamboli,Jeremy A. Squire,Simon Tanguay,Kanishka Sircar +9 more
TL;DR: The authors examined the activation status of different components of the mTOR pathway in RCC metastases and matched primary tumors to identify inhibitors of the mammalian target of rapamycin.
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Assignment of the human prostaglandin-endoperoxide synthase 2 (PTGS2) gene to 1q25 by fluorescence in situ hybridization.
TL;DR: The physical proximity of the PTGS2 gene to that of cytosolic phospholipase A2 (cPLA2) is noted, which could mean that polymorphic markers already determined for the cPLA2 gene may also prove to be useful as markers for the PT GS2 gene as well.
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Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation
Khaldoun Al-Romaih,Gino R. Somers,Jane Bayani,Simon Hughes,Mona Prasad,Jean-Claude Cutz,Hui Xue,Maria Zielenska,Yuzhuo Wang,Jeremy A. Squire,Jeremy A. Squire +10 more
TL;DR: Biological evidence is provided that one mode of action of decitabine may be the induction of apoptosis utilizing promoter-CpG demethylation of specific effectors in cell death pathways in OS.
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Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma
Naoki Yanagawa,Charles Leduc,Derek Kohler,Mauro Saieg,Thomas John,Jenna Sykes,Maisa Yoshimoto,Melania Pintilie,Jeremy A. Squire,Frances A. Shepherd,Ming-Sound Tsao,Ming-Sound Tsao +11 more
TL;DR: Absence of PTEN protein expression is an independent prognostic marker in early-stage resected lung adenocarcinoma and the prognostic value of absent PTEN staining was limited to adenOCarcinomas, with MV disease-free survival hazard ratio of 2.68.
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High-resolution cDNA microarray CGH mapping of genomic imbalances in osteosarcoma using formalin-fixed paraffin-embedded tissue.
M. Zielenska,Paula Marrano,Paul S. Thorner,J. Pei,Ben Beheshti,Michael Ho,Jane Bayani,Y. Liu,B.C. Sun,Jeremy A. Squire,Jeremy A. Squire,X.-S. Hao +11 more
TL;DR: A cDNA/EST microarray including 18,980 human cDNAs (which represent all 22 pairs of autosomal chromosomes and chromosome X) was used for CGH analysis of eight OS FFPE, and Chromosomes 1, 12, 17, and X harbored the most imbalances.