J
Jeremy A. Squire
Researcher at University of São Paulo
Publications - 349
Citations - 41173
Jeremy A. Squire is an academic researcher from University of São Paulo. The author has contributed to research in topics: Comparative genomic hybridization & Fluorescence in situ hybridization. The author has an hindex of 87, co-authored 344 publications receiving 38764 citations. Previous affiliations of Jeremy A. Squire include University of Toronto & Kingston General Hospital.
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Book ChapterDOI
Genetic aspects of bone tumors
TL;DR: The advent of the human genome map and molecular techniques, such as microarray-based copy number and gene expression profiling, provide a new approach to classifying tumors and promise to improve the ability to predict both the probability of metastasis and overall clinical course.
Journal ArticleDOI
Precision medicine for prostate cancer—improved outcome prediction for low-intermediate risk disease using a six-gene copy number alteration classifier
TL;DR: In this article , a multiplex 6-gene copy number classifier was used to distinguish between low- or intermediate-risk prostate cancer patients, and the classifier performs better than conventional stratification methods, is low cost, and can be performed easily in clinical laboratories.
Journal ArticleDOI
Detection of Mitotic Figures and Components of the Mitotic Machinery
Jane Bayani,Jeremy A. Squire +1 more
TL;DR: Variations in cell culturing and fixation methods enhance the visualization of mitotic figures, and immunohistochemistry using a host of antibodies against protein structures involved in the cell cycle as well as against those components involved in anchoring chromosomal structures can reveal changes in chromosomal segregation.
Journal ArticleDOI
PTEN loss in Gleason grade 7 prostate tumors exhibits intratumoral heterogeneity and is associated with unfavorable pathological features
Clarissa Gondim Picanço-Albuquerque,Thiago Vidotto,Ciro Silveira Pereira,Fabiano Pinto Saggioro,Tamara Jamaspishvili,Madhuri Koti,David M. Berman,Jeremy A. Squire,Jeremy A. Squire,Rodolfo Borges dos Reis +9 more
TL;DR: This study shows that PTEN loss in Gleason grade 7 tumors can be heterogeneous and that a systematic analysis of this biomarker using a combination of FISH, IHC, and digital imaging may identify patients with a greater risk of poor outcome.
Journal ArticleDOI
Partial Monosomy 4p and Trisomy 12q due to a t(4;12)(p16.3;q24.31) Familial Translocation in Two Cousins
T. M. Joaquim,Carlos Henrique Paiva Grangeiro,Flávia Gaona de Oliveira Gennaro,A. G. Gomes,Jeremy A. Squire,Jeremy A. Squire,Lúcia Regina Martelli +6 more
TL;DR: Analysis of the literature of 3 similar translocations involving 4p and 12q, together with the clinical features of the affected cousins in this familial translocation, permits an evaluation of genes closely linked to WHSC1 and WHSC2 in the context of WHS and the genes involved in 12q trisomy.