B
Bernard Gerrard
Researcher at Science Applications International Corporation
Publications - 42
Citations - 7925
Bernard Gerrard is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Gene & Cystic fibrosis. The author has an hindex of 25, co-authored 42 publications receiving 7655 citations. Previous affiliations of Bernard Gerrard include Business International Corporation & National Institutes of Health.
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Journal ArticleDOI
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Heidi Hahn,Carol Wicking,Peter G. Zaphiropoulos,Mae R. Gailani,Susan Shanley,Abirami Chidambaram,Igor Vorechovsky,Erika Holmberg,Anne Birgitte Undén,Susan Gillies,Kylie Negus,Ian M. Smyth,Carolyn Pressman,David J. Leffell,Bernard Gerrard,Alisa M. Goldstein,Michael Dean,Rune Toftgård,Georgia Chenevix-Trench,Brandon J. Wainwright,Allen E. Bale +20 more
TL;DR: It is proposed that a reduction in expression of the patched gene can lead to the developmental abnormalities observed in the syndrome and that complete loss of patched function contributes to transformation of certain cell types.
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A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
Rando Allikmets,Nanda A. Singh,Hui Sun,Noah F. Shroyer,Amy Hutchinson,Abirami Chidambaram,Bernard Gerrard,Lisa Baird,Dora Stauffer,Andy Peiffer,Amir Rattner,Philip M. Smallwood,Yixin Li,Kent L. Anderson,Richard A. Lewis,Jeremy Nathans,Mark Leppert,Michael Dean,James R. Lupski +18 more
TL;DR: Mutational analysis of ABCR in STGD families revealed a total of 19 different mutations including homozygous mutations in two families with consanguineous parentage, indicating that ABCR is the causal gene of STGD/FFM.
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Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes
J. Claiborne Stephens,David Reich,David Goldstein,Hyoung Doo Shin,Michael W. Smith,Mary Carrington,Cheryl A. Winkler,Gavin A. Huttley,Rando Allikmets,Lynn M. Schriml,Bernard Gerrard,Michael Malasky,Maria D. Ramos,Susanne Morlot,Maria Tzetis,Carole Oddoux,Francesco S. di Giovine,Georgios Nasioulas,David Chandler,Michael Aseev,Matthew Hanson,Luba Kalaydjieva,Damjan Glavač,Paolo Gasparini,Emmanuel Kanavakis,Mireille Claustres,Marios Kambouris,Harry Ostrer,Gordon W. Duff,Vladislav S Baranov,Hiljar Sibul,Andres Metspalu,David Goldman,Nicholas G. Martin,David L. Duffy,Jörg Schmidtke,Xavier Estivill,Stephen J. O'Brien,Michael Dean +38 more
TL;DR: The geographic cline of CCR5-Delta32 frequencies and its recent emergence are consistent with a historic strong selective event, driving its frequency upward in ancestral Caucasian populations.
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Congenital bilateral absence of the vas deferens. A primarily genital form of cystic fibrosis
Arturo Anguiano,Robert D. Oates,Jean A. Amos,Michael Dean,Bernard Gerrard,Claudia Stewart,Thomas A. Maher,Marga Belle White,Aubrey Milunsky +8 more
TL;DR: Some, if not all, otherwise healthy men with CBAVD reflect a newly recognized, primarily genital, phenotype of CF, and CF mutation analysis should be recommended for them and their partners, as well as for their relatives.
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Novel mutations of the MET proto-oncogene in papillary renal carcinomas.
Laura S. Schmidt,Kerstin Junker,Noboru Nakaigawa,T. Kinjerski,Gregor Weirich,M. Miller,Irina A. Lubensky,Hartmut P. H. Neumann,Hiltrud Brauch,Jochen Decker,Cathy D. Vocke,J. A. Brown,Robert B. Jenkins,Stéphane Richard,Ulf S.R. Bergerheim,Bernard Gerrard,Michael Dean,W. M. Linehan,Berton Zbar +18 more
TL;DR: The low frequency of MET mutations in noninherited papillary renal carcinomas (PRC) suggests that non inherited PRC may develop by a different mechanism than hereditary papillary kidneys carcinoma.