D
David Lillicrap
Researcher at Queen's University
Publications - 377
Citations - 13743
David Lillicrap is an academic researcher from Queen's University. The author has contributed to research in topics: Von Willebrand disease & Von Willebrand factor. The author has an hindex of 59, co-authored 350 publications receiving 12189 citations. Previous affiliations of David Lillicrap include University of Calgary & Children's Hospital of Philadelphia.
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Journal ArticleDOI
Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor
J E Sadler,U. Budde,Jeroen Eikenboom,Emmanuel J. Favaloro,Frank Hill,Lars Holmberg,Jørgen Ingerslev,Christine A. Lee,David Lillicrap,P. M. Mannucci,Claudine Mazurier,Dominique Meyer,William L. Nichols,M. Nishino,Ian R. Peake,F. Rodeghiero,Reinhard Schneppenheim,Zaverio M. Ruggeri,A. Srivastava,Robert R. Montgomery,Augusto B. Federici +20 more
TL;DR: Six categories of von Willebrand disease correlate with important clinical features and therapeutic requirements, and certain VWD types, especially type 1 and type 2A, encompass several pathophysiologic mechanisms that sometimes can be distinguished by appropriate laboratory studies.
Journal ArticleDOI
ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders
F. Rodeghiero,Alberto Tosetto,Thomas C. Abshire,Donald M. Arnold,Barry S. Coller,Paula D. James,Cindy E. Neunert,David Lillicrap +7 more
Journal ArticleDOI
Factor VIII gene inversions in severe hemophilia A: results of an international consortium study
Stylianos E. Antonarakis,J. P. Rossiter,M. Young,J. Horst,P. De Moerloose,S. S. Sommer,Rhett P. Ketterling,H. H. Kazazian,Claude Negrier,Christine Vinciguerra,Jane Gitschier,Michel Goossens,E. Girodon,N. Ghanem,F. Plassa,Jean-Maurice Lavergne,M. Vidaud,J. M. Costa,Y. Laurian,S. W. Lin,S. R. Lin,M. C. Shen,David Lillicrap,Sherryl A. M. Taylor,S. Windsor,Sophie Valleix,K. Nafa,Y. Sultan,Marc Delpech,Cindy L. Vnencak-Jones,John A. Phillips,Rolf Ljung,E. Koumbarelis,A. Gialeraki,T. Mandalaki,P. V. Jenkins,Peter William Collins,K. J. Pasi,Anne Goodeve,Ian R. Peake,F. E. Preston,Marianne Schwartz,Elma Scheibel,Jørgen Ingerslev,David Neil Cooper,David Stuart Millar,V. V. Kakkar,F. Giannelli,J.A. Naylor,E. F. Tizzano,M. Baiget,M. Domenech,Carmen Altisent,J. Tusell,M. Beneyto,J. I. Lorenzo,Christine Gaucher,Claudine Mazurier,Kathelijne Peerlinck,Gert Matthijs,Jj. Cassiman,Jozef Vermylen,P. G. Mori,M. Acquila,D. Caprino,Hiroshi Inaba +65 more
TL;DR: The presence of factor VII inversions is not a major predisposing factor for the development of factor VIII inhibitors; however, slightly more patients with severe hemophilia A and factor VIII inversions develop inhibitors than patients without inversions.
Journal ArticleDOI
The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study
Paula D. James,Colleen Notley,Carol Hegadorn,Jayne Leggo,Angie Tuttle,Shawn Tinlin,Christine Brown,Chandler Andrews,Andrea Labelle,Yvette Chirinian,Lee A. O'Brien,Maha Othman,Georges E. Rivard,D. Rapson,Christine Hough,David Lillicrap +15 more
TL;DR: A large multicenter Canadian study was conducted to evaluate the changes within the VWF gene that might contribute to the pathogenesis of type 1 von Willebrand disease (VWD) as discussed by the authors.
Journal Article
The mutational spectrum of type 1 von Willebrand disease : results from a Canadian cohort study. Commentary
J. Evan Sadler,Paula D. James,Colleen Notley,Carol Hegadorn,Jayne Leggo,Angie Tuttle,Shawn Tinlin,Christine E. Brown,Chandler Andrews,Andrea Labelle,Yvette Chirinian,Lee A. O'Brien,Maha Othman,Georges E. Rivard,D. Rapson,Christine Hough,David Lillicrap +16 more
TL;DR: It was somewhat more likely to identify putative mutations in cases with lower VWF levels, and the contribution of other factors, such as ABO blood group, seems more important in milder cases.