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Jérôme Ruel

Researcher at Aix-Marseille University

Publications -  37
Citations -  3286

Jérôme Ruel is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Hair cell & Spiral ganglion. The author has an hindex of 25, co-authored 35 publications receiving 2958 citations. Previous affiliations of Jérôme Ruel include Centre national de la recherche scientifique & University of Montpellier.

Papers
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Journal ArticleDOI

Ryanodine receptors and BK channels act as a presynaptic depressor of neurotransmission in cochlear inner hair cells.

Maryline Beurg, +8 more
- 01 Sep 2005 - 
TL;DR: It is proposed that coupled RyR–BK channels act to suppress the fast neurotransmission in IHCs through inhibitory action of ryanodine on presynaptic BK channels of inner hair cells (IHC).
Journal ArticleDOI

Negative allosteric modulation of AMPA-preferring receptors by the selective isomer GYKI 53784 (LY303070), a specific non-competitive AMPA antagonist.

Jérôme Ruel, +2 more
- 07 Jun 2006 - 
TL;DR: GYKI 53784 is the most potent of the compounds in the 2,3-benzodiazepine class, blocking AMPA receptor-mediated responses, and may be of potential clinical value, both in acute (stroke and trauma) and chronic neurological disorders.
Patent

Methods for the treatment of tinnitus induced by cochlear excitotoxicity

Matthieu J. Guitton, +4 more
TL;DR: In this article, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and/or formulations for local administration to the inner ear.
Journal ArticleDOI

Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache.

Caroline Bonnet, +6 more
- 18 Sep 2019 - 
TL;DR: Anomalous activation of Nav1.9 channels by Nitric Oxide is responsible for triptan-induced MOH, causing hyperexcitability of dural nociceptors and headache, and analysis of signaling networks indicates that PKA is downregulated in trigeminal neurons from MOH mice, relieving its inhibitory action on NO-Nav1.
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Coxsackie adenovirus receptor and alpha nu beta3/alpha nu beta5 integrins in adenovirus gene transfer of rat cochlea.

Frédéric Venail, +13 more
- 01 Jan 2007 - 
TL;DR: It is found that CAR and integrin co-receptors are expressed in every cell subtype transduced by the adenoviral vector Ad5 ΔE1–E3/cytomegalovirus/green fluorescent protein (GFP) on cochlear slices in vitro.