R
Régis Nouvian
Researcher at French Institute of Health and Medical Research
Publications - 33
Citations - 2972
Régis Nouvian is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hair cell & Ribbon synapse. The author has an hindex of 20, co-authored 33 publications receiving 2651 citations. Previous affiliations of Régis Nouvian include University of Göttingen & University of Montpellier.
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Journal ArticleDOI
Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse
Isabelle Roux,Saaid Safieddine,Régis Nouvian,M'hamed Grati,M'hamed Grati,Marie-Christine Simmler,Amel Bahloul,Isabelle Perfettini,Morgane Le Gall,Philippe Rostaing,Ghislaine Hamard,Antoine Triller,Paul Avan,Tobias Moser,Christine Petit +14 more
TL;DR: Otoferlin is essential for a late step of synaptic vesicle exocytosis and may act as the major Ca(2+) sensor triggering membrane fusion at the IHC ribbon synapse.
Journal ArticleDOI
Hair cell synaptic ribbons are essential for synchronous auditory signalling
Darina Khimich,Régis Nouvian,Régis Nouvian,Rémy Pujol,Susanne tom Dieck,Susanne tom Dieck,Alexander Egner,Eckart D. Gundelfinger,Tobias Moser +8 more
TL;DR: It is concluded that ribbon-dependent synchronous release of multiple vesicles at the hair cell afferent synapse is essential for normal hearing.
Journal ArticleDOI
Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness
Tatjana Kharkovets,Karin Dedek,Hannes Maier,Michaela Schweizer,Darina Khimich,Régis Nouvian,Vitya Vardanyan,Rudolf Leuwer,Tobias Moser,Thomas J. Jentsch +9 more
TL;DR: It is concluded that the hearing loss in DFNA2 is predominantly caused by a slow degeneration of OHCs resulting from chronic depolarization.
Journal ArticleDOI
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.
Jérôme Ruel,Jérôme Ruel,S. Emery,Régis Nouvian,Tiphaine Bersot,Tiphaine Bersot,Bénédicte Amilhon,Jana M. Van Rybroek,Guy Rebillard,Guy Rebillard,Marc Lenoir,Marc Lenoir,Michel Eybalin,Michel Eybalin,Benjamin Delprat,Benjamin Delprat,Theru A. Sivakumaran,Bruno Giros,Salah El Mestikawy,Tobias Moser,Richard J.H. Smith,Marci M. Lesperance,Jean-Luc Puel,Jean-Luc Puel +23 more
TL;DR: It is concluded that deafness in Slc17a8-deficient mice is due to a specific defect of vesicular glutamate uptake and release and that VGLUT3 is essential for auditory coding at the IHC synapse.
Journal ArticleDOI
Structure and function of the hair cell ribbon synapse.
TL;DR: This review focuses on major advances in understanding the hair cell afferent synapse molecular anatomy and function that have been achieved during the past years.