J
Jérôme Ruel
Researcher at Aix-Marseille University
Publications - 37
Citations - 3286
Jérôme Ruel is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Hair cell & Spiral ganglion. The author has an hindex of 25, co-authored 35 publications receiving 2958 citations. Previous affiliations of Jérôme Ruel include Centre national de la recherche scientifique & University of Montpellier.
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Journal ArticleDOI
The selective AMPA receptor antagonist GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea.
TL;DR: Results suggest that AMPA-preferring receptors are functionally located at the sensory cell-afferent synapse whereas NMDA and kainate receptors are not.
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Implication of nmda type glutamate receptors in neural regeneration and neoformation of synapses after excitotoxic injury in the guinea pig cochlea
TL;DR: The findings of this study support the hypothesis that, in addition to acting as a fast transmitter, glutamate has a neurotrophic role via the activation of NMDA receptors.
Journal ArticleDOI
The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia
Stéphane Lolignier,Stéphane Lolignier,Caroline Bonnet,Christelle Gaudioso,Jacques Noël,Jérôme Ruel,Muriel Amsalem,Jérémy Ferrier,Jérémy Ferrier,Lise Rodat-Despoix,Valentine Bouvier,Youssef Aissouni,Youssef Aissouni,Laetitia Prival,Laetitia Prival,Eric Chapuy,Eric Chapuy,Françoise Padilla,Alain Eschalier,Alain Eschalier,Patrick Delmas,Jérôme Busserolles,Jérôme Busserolles +22 more
TL;DR: It is shown that the voltage-gated Nav1.9 sodium channel is important for the perception of pain in response to noxious cold and acts as a subthreshold amplifier in cold-sensitive nociceptive neurons and is required for the Perception of cold pain under normal and pathological conditions.
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The inner hair cell synaptic complex: physiology, pharmacology and new therapeutic strategies.
TL;DR: This presentation reviews the most recent findings obtained at the IHC synaptic complex with an original technique, namely coupling auditory nerve single unit recordings with multibarrel intracochlear perfusions.
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Transient Ca2+-permeable AMPA receptors in postnatal rat primary auditory neurons.
TL;DR: It is reported that AMPA receptors at inner hair cell (IHC) synapses lack the GluR2 subunit and are transiently Ca2+‐permeable before hearing onset as evidenced using agonist‐induced Co2+ accumulation, Western blots and Glu R2 confocal microscopy in the rat cochlea.