J
Jerry S.H. Lee
Researcher at University of Southern California
Publications - 61
Citations - 5607
Jerry S.H. Lee is an academic researcher from University of Southern California. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 22, co-authored 53 publications receiving 4866 citations. Previous affiliations of Jerry S.H. Lee include Uniformed Services University of the Health Sciences & National Institutes of Health.
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Journal ArticleDOI
Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds
Forrest M. Kievit,Stephen J. Florczyk,Matthew Leung,Kui Wang,Jennifer D. Wu,John R. Silber,Richard G. Ellenbogen,Jerry S.H. Lee,Jerry S.H. Lee,Miqin Zhang +9 more
TL;DR: It is reported that growing cells from glioblastoma cell lines on 3D porous chitosan-alginate (CA) scaffolds dramatically promotes the proliferation and enrichment of cells possessing the hallmarks of CSCs.
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Microrheology and ROCK Signaling of Human Endothelial Cells Embedded in a 3D Matrix
TL;DR: It is found that VEGF treatment, which enhances endothelial migration, increases the compliance and reduces the elasticity of the cytoplasm of HUVECs in a matrix, is abrogated by specific Rho-kinase (ROCK) inhibition, suggesting that ROCK plays an essential role in the regulation of the intracellular mechanical response to VEGFs.
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Cdc42 Mediates Nucleus Movement and MTOC Polarization in Swiss 3T3 Fibroblasts under Mechanical Shear Stress
TL;DR: It is reported that nuclei of Swiss 3T3 fibroblasts undergo enhanced movement when subjected to shear flows, and it is proposed that the movements of MTOC and nucleus are coupled chemically, because they are both regulated by Cdc42 and dependent on microtubule structure, and physically via Hook/SUN family homologues similar to those found in Caenorhabditis elegans.
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Biophysical and biomolecular determination of cellular age in humans
Jude M. Phillip,Pei Hsun Wu,Daniele M. Gilkes,Daniele M. Gilkes,Wadsworth Williams,Shaun McGovern,Jena Daya,Jonathan H. Chen,Ivie Aifuwa,Jerry S.H. Lee,Rong Fan,Jeremy D. Walston,Denis Wirtz +12 more
TL;DR: It is shown that the degradation of functional cellular biophysical features-including cell mechanics, traction strength, morphology and migratory potential-and associated descriptors of cellular heterogeneity predict cellular age with higher accuracy than conventional biomolecular markers.
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Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells.
Forrest M. Kievit,Ashleigh Cooper,Soumen Jana,Matthew Leung,Kui Wang,Dennis Edmondson,David M. Wood,Jerry S.H. Lee,Jerry S.H. Lee,Richard G. Ellenbogen,Miqin Zhang +10 more
TL;DR: The ability of chitosan‐polycaprolactone polyblend nanofibers to promote a migratory phenotype in human GBM cells by altering the nanotopography of the nanofiber membranes is investigated.