J
Jessica Z. Kubicek-Sutherland
Researcher at Los Alamos National Laboratory
Publications - 39
Citations - 1056
Jessica Z. Kubicek-Sutherland is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 10, co-authored 28 publications receiving 731 citations. Previous affiliations of Jessica Z. Kubicek-Sutherland include Uppsala University & University of California, Santa Barbara.
Papers
More filters
Journal ArticleDOI
Mechanisms and consequences of bacterial resistance to antimicrobial peptides
TL;DR: Routine clinical administration of AMPs to treat bacterial infections may select for resistant bacterial pathogens capable of better evading the innate immune system, as well as the ramifications of therapeutic levels of exposure on the development of AMP resistance and bacterial pathogenesis.
Journal ArticleDOI
Rapid detection of Mycobacterium tuberculosis biomarkers in a sandwich immunoassay format using a waveguide-based optical biosensor.
Harshini Mukundan,Sandeep Kumar,Dominique N. Price,Sonja M. Ray,Ye Jin Lee,Seonyeong Min,Seokyong Eum,Jessica Z. Kubicek-Sutherland,Jesse M. Resnick,W. Kevin Grace,Aaron S. Anderson,Soo Hee Hwang,Sang Nae Cho,Laura E. Via,Clifton E. Barry,Ramamurthy Sakamuri,Basil I. Swanson +16 more
TL;DR: The development of sandwich immunoassays for the direct detection of three TB-specific biomarkers, namely LAM, early secretory antigenic target 6 (ESAT6) and antigen 85 complex (Ag85), using a waveguide-based optical biosensor platform are demonstrated.
Journal ArticleDOI
Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides
Jessica Z. Kubicek-Sutherland,Hava Lofton,Martin Vestergaard,Karin Hjort,Hanne Ingmer,Dan I. Andersson +5 more
TL;DR: In vitro serial passage of a clinical USA300 MRSA strain in a host-mimicking environment containing host-derived AMPs results in the selection of stable AMP resistance, suggesting that therapeutic use of AMPs could select for virulent mutants with cross-resistance to human innate immunity as well as antibiotic therapy.
Journal ArticleDOI
Transfer and Persistence of a Multi-Drug Resistance Plasmid in situ of the Infant Gut Microbiota in the Absence of Antibiotic Treatment.
Heidi Gumpert,Heidi Gumpert,Jessica Z. Kubicek-Sutherland,Andreas Porse,Nahid Karami,Christian Munck,Marius Linkevicius,Ingegerd Adlerberth,Agnes E. Wold,Dan I. Andersson,Morten Otto Alexander Sommer +10 more
TL;DR: The results exemplify that conjugative plasmids, harboring resistance determinants, can transfer and persists in the gut in the absence of antibiotic treatment, and provide the first genomic description of antibiotic resistance gene transfer between bacteria in the unperturbed human gut.
Journal ArticleDOI
Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure.
Jessica Z. Kubicek-Sutherland,Douglas M. Heithoff,Selvi C. Ersoy,William R. Shimp,John K. House,Jamey D. Marth,Jamey D. Marth,Jeffrey W. Smith,Michael J. Mahan +8 more
TL;DR: It is revealed that a bacterial mechanism that promotes antibiotic resistance in vivo at concentrations of drug that far exceed dosages determined by standardized antimicrobial testing has escaped prior detection.