Mechanisms and consequences of bacterial resistance to antimicrobial peptides
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TLDR
Routine clinical administration of AMPs to treat bacterial infections may select for resistant bacterial pathogens capable of better evading the innate immune system, as well as the ramifications of therapeutic levels of exposure on the development of AMP resistance and bacterial pathogenesis.About:
This article is published in Drug Resistance Updates.The article was published on 2016-05-01 and is currently open access. It has received 484 citations till now. The article focuses on the topics: Antimicrobial peptides & Population.read more
Citations
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The antimicrobial activity of nanoparticles: present situation and prospects for the future
TL;DR: The antibacterial mechanisms of NPs against bacteria and the factors that are involved are discussed and the limitations of current research are discussed.
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Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
Margit Mahlapuu,Margit Mahlapuu,Joakim Håkansson,Lovisa Ringstad,Camilla Björn,Camilla Björn +5 more
TL;DR: An overview of the biological role, classification, and mode of action of AMPs is provided, the opportunities and challenges to develop these peptides for clinical applications are discussed, and the innovative formulation strategies for application are reviewed.
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Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo
TL;DR: The diversity, history and the various mechanisms of action of AMPs are discussed, and some of the recent strategies developed to improve the activity and biocompatibility of AMP are reviewed.
Journal ArticleDOI
Antimicrobial host defence peptides: functions and clinical potential
TL;DR: The emerging potential to therapeutically harness cationic host defence peptides to treat infectious diseases, chronic inflammatory disorders and wound healing is assessed, highlighting current preclinical studies and clinical trials.
Journal ArticleDOI
Defensins: natural peptide antibiotics in human neutrophils
TL;DR: The defensin system may operate in conjunction with or independently from oxygen-dependent microbicidal processes to enable human neutrophils to inactivate and destroy potential pathogens.
References
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Journal ArticleDOI
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
Book
Isolation and characterization
TL;DR: Animal Models and Therapy, Directed Differentiation and Characterization of Genetically Modified Embryonic Stem Cells for Therapy, and Use of Differentiating Embryonics Stem cells in the Parkinsonian Mouse Model are reviewed.
Journal ArticleDOI
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study
Yiyun Liu,Yang Wang,Timothy R. Walsh,Ling-Xian Yi,Rong Zhang,James Spencer,Yohei Doi,Guo-Bao Tian,Baolei Dong,Xianhui Huang,Lin-Feng Yu,Danxia Gu,Hongwei Ren,Xiaojie Chen,Luchao Lv,Dandan He,Hongwei Zhou,Zi-sen Liang,Jian-Hua Liu,Jianzhong Shen +19 more
TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.
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Mechanisms of Antimicrobial Peptide Action and Resistance
TL;DR: The intention of this review is to illustrate the contemporary structural and functional themes among mechanisms of antimicrobial peptide action and resistance.
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Peptide Antimicrobial Agents
TL;DR: The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides.