J
Jezabel Varadé
Researcher at Hospital Clínico San Carlos
Publications - 37
Citations - 1767
Jezabel Varadé is an academic researcher from Hospital Clínico San Carlos. The author has contributed to research in topics: Single-nucleotide polymorphism & Linkage disequilibrium. The author has an hindex of 20, co-authored 35 publications receiving 1619 citations. Previous affiliations of Jezabel Varadé include Complutense University of Madrid.
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Journal ArticleDOI
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Gosia Trynka,Karen A. Hunt,Nicholas A. Bockett,Jihane Romanos,Vanisha Mistry,Agata Szperl,Sjoerd F. Bakker,Maria Teresa Bardella,Leena Bhaw-Rosun,Gemma Castillejo,Emilio G. de la Concha,Rodrigo Coutinho de Almeida,Kerith-Rae Dias,Cleo C. van Diemen,Patrick Dubois,Richard H. Duerr,Sarah Edkins,Lude Franke,Karin Fransen,Javier Gutierrez,Graham A. Heap,Barbara Hrdličková,Sarah E. Hunt,Leticia Plaza Izurieta,V. Izzo,Leo A. B. Joosten,Cordelia Langford,Maria Cristina Mazzilli,Charles A. Mein,Vandana Midah,Mitja Mitrovic,Barbara Mora,Marinita Morelli,Sarah Nutland,Concepción Núñez,Suna Onengut-Gumuscu,Kerra Pearce,Mathieu Platteel,Isabel Polanco,Simon C. Potter,Carmen Ribes-Koninckx,Isis Ricaño-Ponce,Stephen S. Rich,Anna Rybak,Jose Luis Santiago,Sabyasachi Senapati,Ajit Sood,Hania Szajewska,Riccardo Troncone,Jezabel Varadé,Chris Wallace,Victorien M. Wolters,Alexandra Zhernakova,B.K. Thelma,Bożena Cukrowska,Elena Urcelay,Jose Ramon Bilbao,M. Luisa Mearin,Donatella Barisani,Jeffrey C. Barrett,Vincent Plagnol,Panos Deloukas,Cisca Wijmenga,David A. van Heel +63 more
TL;DR: The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease.
Journal ArticleDOI
Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.
Alfonso Martínez,Jezabel Varadé,Ana Márquez,María Carmen Cenit,L. Espino,Nieves Perdigones,Jose Luis Santiago,Miguel Fernández-Arquero,H. de la Calle,Rafael Arroyo,Juan Luis Mendoza,Benjamín Fernández-Gutiérrez,E G de la Concha,Elena Urcelay +13 more
TL;DR: The STAT4 gene is emerging as a novel common risk factor for diverse complex diseases, including inflammatory bowel disease, Crohn's disease and ulcerative colitis and type 1 diabetes mellitus.
Journal ArticleDOI
Chromosomal region 16p13: further evidence of increased predisposition to immune diseases
Alfonso Martínez,Nieves Perdigones,María Carmen Cenit,L. Espino,Jezabel Varadé,José Ramón Lamas,Jose Luis Santiago,Miguel Fernández-Arquero,H. de la Calle,R. Arroyo,E G de la Concha,Benjamín Fernández-Gutiérrez,Elena Urcelay +12 more
TL;DR: In this paper, the role of CLEC16A polymorphisms in T1D, MS and RA pathogenesis and its relationship with the association reported with a MHC2TA haplotype was tested.
Journal ArticleDOI
Role of the MHC2TA gene in autoimmune diseases
Alfonso Martínez,Marta Sánchez‐Lopez,Jezabel Varadé,Ana Mas,M Carmen Martín,Virginia de las Heras,Rafael Arroyo,Juan Luis Mendoza,Manuel Díaz-Rubio,Benjamín Fernández-Gutiérrez,Emilio G. de la Concha,Elena Urcelay +11 more
TL;DR: The MHC2TA gene influences predisposition to rheumatoid arthritis and multiple sclerosis, but not to IBD, and the −168G allele is not an aetiological variant in itself, but a genetic marker of susceptibility/protection haplotypes.
Journal ArticleDOI
Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients.
Ana Márquez,Jezabel Varadé,Gema Robledo,Alfonso Martínez,Juan Luis Mendoza,Carlos Taxonera,Miguel Fernández-Arquero,Manuel Díaz-Rubio,María Gómez-García,Miguel A. López-Nevot,Emilio G. de la Concha,Javier Martín,Elena Urcelay +12 more
TL;DR: Analysis of association of CLEC16A/KIAA0350 polymorphisms with IBD patients and ethnically matched healthy controls suggests microbial recognition through different pathways seems to converge in the development of these polygenic bowel diseases.