R
Rodrigo Coutinho de Almeida
Researcher at Leiden University Medical Center
Publications - 68
Citations - 2247
Rodrigo Coutinho de Almeida is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 48 publications receiving 1690 citations. Previous affiliations of Rodrigo Coutinho de Almeida include RMIT University & University Medical Center Groningen.
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Journal ArticleDOI
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Gosia Trynka,Karen A. Hunt,Nicholas A. Bockett,Jihane Romanos,Vanisha Mistry,Agata Szperl,Sjoerd F. Bakker,Maria Teresa Bardella,Leena Bhaw-Rosun,Gemma Castillejo,Emilio G. de la Concha,Rodrigo Coutinho de Almeida,Kerith-Rae Dias,Cleo C. van Diemen,Patrick Dubois,Richard H. Duerr,Sarah Edkins,Lude Franke,Karin Fransen,Javier Gutierrez,Graham A. Heap,Barbara Hrdličková,Sarah E. Hunt,Leticia Plaza Izurieta,V. Izzo,Leo A. B. Joosten,Cordelia Langford,Maria Cristina Mazzilli,Charles A. Mein,Vandana Midah,Mitja Mitrovic,Barbara Mora,Marinita Morelli,Sarah Nutland,Concepción Núñez,Suna Onengut-Gumuscu,Kerra Pearce,Mathieu Platteel,Isabel Polanco,Simon C. Potter,Carmen Ribes-Koninckx,Isis Ricaño-Ponce,Stephen S. Rich,Anna Rybak,Jose Luis Santiago,Sabyasachi Senapati,Ajit Sood,Hania Szajewska,Riccardo Troncone,Jezabel Varadé,Chris Wallace,Victorien M. Wolters,Alexandra Zhernakova,B.K. Thelma,Bożena Cukrowska,Elena Urcelay,Jose Ramon Bilbao,M. Luisa Mearin,Donatella Barisani,Jeffrey C. Barrett,Vincent Plagnol,Panos Deloukas,Cisca Wijmenga,David A. van Heel +63 more
TL;DR: The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease.
Journal ArticleDOI
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.
Vinod Kumar,Harm-Jan Westra,Juha Karjalainen,Daria V. Zhernakova,Tõnu Esko,Barbara Hrdličková,Rodrigo Coutinho de Almeida,Rodrigo Coutinho de Almeida,Alexandra Zhernakova,Eva Reinmaa,Urmo Võsa,Marten H. Hofker,Rudolf S N Fehrmann,Jingyuan Fu,Sebo Withoff,Andres Metspalu,Lude Franke,Cisca Wijmenga +17 more
TL;DR: It is shown that this specific genotype-lincRNA expression correlation is tissue-dependent and that many of these lincRNA cis-eQTL SNPs are also associated with complex traits and diseases.
Journal ArticleDOI
Genetic variation in the non-coding genome: Involvement of micro-RNAs and long non-coding RNAs in disease
TL;DR: This article describes their biogenesis, suggested mechanism of action, and discusses how these non-coding RNAs might be affected by disease-associated genetic alterations, and provides an overview of available databases, bioinformatics tools, and high-throughput techniques that can be used to study the mechanisms of action of individual non-CodingRNAs.
Journal ArticleDOI
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cindy G. Boer,Konstantinos Hatzikotoulas,Lorraine Southam,Lilja Stefansdottir,Yanfei Zhang,Rodrigo Coutinho de Almeida,Tian T Wu,Jie Zheng,April Hartley,Maris Teder-Laving,Anne Heidi Skogholt,Chikashi Terao,Eleni Zengini,George Alexiadis,Andrei Barysenka,Gyda Bjornsdottir,Maiken Elvestad Gabrielsen,Arthur Gilly,Thorvaldur Ingvarsson,Marianne B Johnsen,Helgi Jonsson,Margreet Kloppenburg,Almut Luetge,Sigrun H. Lund,Reedik Mägi,Massimo Mangino,Rob G H H Nelissen,Manu Shivakumar,Julia Steinberg,Hiroshi Takuwa,Laurent F. Thomas,Margo Tuerlings,Hunt All-In Pain,George C. Babis,Jason Pui Yin Cheung,Jae Hee Kang,Peter Kraft,Steven A Lietman,Dino Samartzis,P. Eline Slagboom,Kari Stefansson,Unnur Thorsteinsdottir,Jonathan H Tobias,André G. Uitterlinden,Bendik S. Winsvold,John-Anker Zwart,George Davey Smith,Pak C. Sham,Gudmar Thorleifsson,Tom R. Gaunt,Andrew P. Morris,Ana M. Valdes,Aspasia Tsezou,Kathryn S.E. Cheah,Shiro Ikegawa,Kristian Hveem,Tõnu Esko,J. Mark Wilkinson,Ingrid Meulenbelt,Ming Ta Michael Lee,Joyce B. J. van Meurs,Unnur Styrkarsdottir,Eleftheria Zeggini +62 more
TL;DR: A genome-wide association study meta-analysis across 826,690 individuals and identifies 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before.
Journal ArticleDOI
RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage.
Rodrigo Coutinho de Almeida,Yolande F M Ramos,Ahmed Mahfouz,Wouter den Hollander,Nico Lakenberg,E. Houtman,Marcella van Hoolwerff,H. Eka D. Suchiman,Alejandro Rodríguez Ruiz,P. Eline Slagboom,Hailiang Mei,Szymon M. Kielbasa,Rob G H H Nelissen,Marcel J. T. Reinders,Ingrid Meulenbelt +14 more
TL;DR: The authors' functional data demonstrated interacting levels at which miRNA affects expression of genes in the cartilage and exemplified the complexity of functionally validating a network of genes that may be targeted by multiple miRNAs.