B
Barbara Hrdličková
Researcher at University Medical Center Groningen
Publications - 19
Citations - 1918
Barbara Hrdličková is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 15, co-authored 18 publications receiving 1669 citations. Previous affiliations of Barbara Hrdličková include University of Groningen & Utrecht University.
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Journal ArticleDOI
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
Gosia Trynka,Karen A. Hunt,Nicholas A. Bockett,Jihane Romanos,Vanisha Mistry,Agata Szperl,Sjoerd F. Bakker,Maria Teresa Bardella,Leena Bhaw-Rosun,Gemma Castillejo,Emilio G. de la Concha,Rodrigo Coutinho de Almeida,Kerith-Rae Dias,Cleo C. van Diemen,Patrick Dubois,Richard H. Duerr,Sarah Edkins,Lude Franke,Karin Fransen,Javier Gutierrez,Graham A. Heap,Barbara Hrdličková,Sarah E. Hunt,Leticia Plaza Izurieta,V. Izzo,Leo A. B. Joosten,Cordelia Langford,Maria Cristina Mazzilli,Charles A. Mein,Vandana Midah,Mitja Mitrovic,Barbara Mora,Marinita Morelli,Sarah Nutland,Concepción Núñez,Suna Onengut-Gumuscu,Kerra Pearce,Mathieu Platteel,Isabel Polanco,Simon C. Potter,Carmen Ribes-Koninckx,Isis Ricaño-Ponce,Stephen S. Rich,Anna Rybak,Jose Luis Santiago,Sabyasachi Senapati,Ajit Sood,Hania Szajewska,Riccardo Troncone,Jezabel Varadé,Chris Wallace,Victorien M. Wolters,Alexandra Zhernakova,B.K. Thelma,Bożena Cukrowska,Elena Urcelay,Jose Ramon Bilbao,M. Luisa Mearin,Donatella Barisani,Jeffrey C. Barrett,Vincent Plagnol,Panos Deloukas,Cisca Wijmenga,David A. van Heel +63 more
TL;DR: The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease.
Journal ArticleDOI
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.
Vinod Kumar,Harm-Jan Westra,Juha Karjalainen,Daria V. Zhernakova,Tõnu Esko,Barbara Hrdličková,Rodrigo Coutinho de Almeida,Rodrigo Coutinho de Almeida,Alexandra Zhernakova,Eva Reinmaa,Urmo Võsa,Marten H. Hofker,Rudolf S N Fehrmann,Jingyuan Fu,Sebo Withoff,Andres Metspalu,Lude Franke,Cisca Wijmenga +17 more
TL;DR: It is shown that this specific genotype-lincRNA expression correlation is tissue-dependent and that many of these lincRNA cis-eQTL SNPs are also associated with complex traits and diseases.
Journal ArticleDOI
Genetic variation in the non-coding genome: Involvement of micro-RNAs and long non-coding RNAs in disease
TL;DR: This article describes their biogenesis, suggested mechanism of action, and discusses how these non-coding RNAs might be affected by disease-associated genetic alterations, and provides an overview of available databases, bioinformatics tools, and high-throughput techniques that can be used to study the mechanisms of action of individual non-CodingRNAs.
Journal ArticleDOI
The influence of a short-term gluten-free diet on the human gut microbiome
Marc Jan Bonder,Ettje F. Tigchelaar,Xianghang Cai,Gosia Trynka,María Carmen Cenit,Barbara Hrdličková,Huanzi Zhong,Tommi Vatanen,Tommi Vatanen,Dirk Gevers,Cisca Wijmenga,Yang Wang,Alexandra Zhernakova +12 more
TL;DR: A GFD changes the gut microbiome composition and alters the activity of microbial pathways and observes strong relations between the predicted activity of pathways and biomarker measurements.
Journal ArticleDOI
Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity
Barbara Hrdličková,Vinod Kumar,Kartiek Kanduri,Daria V. Zhernakova,Subhash K. Tripathi,Juha Karjalainen,Riikka Lund,Yang Li,Ubaid Ullah,Rutger Modderman,Wayel H. Abdulahad,Harri Lähdesmäki,Harri Lähdesmäki,Lude Franke,Riitta Lahesmaa,Cisca Wijmenga,Sebo Withoff +16 more
TL;DR: It is shown that co-expression analyses of lncRNAs and protein-coding genes can predict the signaling pathways in which these AID-associated lnc RNAs are involved and suggests that lncRNA genes should be studied in more detail to interpret GWAS findings correctly.