Jian-Hua Liu

TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.

TL;DR: The prevalence of MCRPE in human infections and carriage, clinical associations of mcr-1-positive Escherichia coli (M CRPEC) infection, and risk factors for MCRPEC carriage are reported.

TL;DR: Liu et al. as discussed by the authors reported the emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study.

TL;DR: The retrospective study documents that the mcr-1 gene has already established itself in highly drugresistant Enterobacteriaceae species, including its movement into carbapenem-resistant strains carrying an NDM-5 resistance plasmid, and the coexistence of MCR-1 resistance and the N DM-5 approaches a pandrugresistant phenotype.

TL;DR: Three kinds of plasmid-mediated quinolone resistance (PMQR) determinants have been discovered and have been shown to be widely distributed among clinical isolates: qnr genes, aac(6′)-Ib-cr, and qepA, and their genotypes were determined.