Yiyun Liu

TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.

TL;DR: It is concluded that IncI2, IncX4, and IncHI2 were the major plasmid types driving the dissemination of mcr-1 in this farm and worldwide and increased fitness or co-selection by other antimicrobials might contribute to the further dissemination of the three epidemic mCr-1–positive plasmids.

TL;DR: The high frequency of colistin resistance and mcr-1 gene among E. coli isolates from food animals in China urged the need to minimize potential risks of colistsin resistance development and the spread of mcr -1 gene.

TL;DR: The results showed a surprisingly high prevalence of fosA3 gene in E. coli isolates recovered from chicken in China, which can be attributed to horizontal dissemination of several epidemic plasmids, especially F33:A-:B- plasmid.

TL;DR: The mcr-1 gene was detected in 21 Salmonella isolates from pigs at slaughter; 19 were serovar Typhimurium sequence type 34 and the gene was located on IncHI2-like plasmids that also harbored IncF replicons and lacked a conjugative transfer region.