Jian-Sheng Kang

TL;DR: A role for axon-targeted syntaphilin (SNPH) in mitochondrial docking through its interaction with microtubules is reported, demonstrating a molecular mechanism for controlling mitochondrial docking in axons that has a physiological impact on synaptic function.

TL;DR: It is proposed that fluoxetine, a selective serotonin reuptake inhibitor, has the potential to treat AD and the combination of hypometabolism and autophagy deficiency is likely to be a causative factor for AD.

TL;DR: It is underscore that vesicular transporter expression is used endogenously to directly regulate the extent of glutamate release, providing a concise presynaptic mechanism for controlling the quantal efficacy of excitatory transmission during synaptic refinement and plasticity.

TL;DR: It is demonstrated that the development of bona fide liver cancer can be modelled at structural and molecular levels by introducing c-Myc into directly reprogrammed human hepatocytes with inactivated p53 and RB and the combined inhibition of Notch and JAK–STAT.

TL;DR: It is shown that the glycine site of the NMDA receptor at hippocampal synapses, both in culture and acute brain slices, is not saturated by the ambient coagonist concentration and is modulated through activity-dependent coagonist release, suggesting that theNMDA receptor glycineSite may serve as a detector of the spatiotemporal characteristics of presynaptic activity patterns.