Z
Zhixin Qiu
Researcher at University of California, San Diego
Publications - 32
Citations - 1477
Zhixin Qiu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Stem cell. The author has an hindex of 12, co-authored 20 publications receiving 692 citations. Previous affiliations of Zhixin Qiu include Chinese Academy of Sciences.
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Journal ArticleDOI
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
Lihua Min,Yuan Ji,Latifa Bakiri,Zhixin Qiu,Jin Cen,Xiaotao Chen,Lingli Chen,Harald Scheuch,Hai Zheng,Lun-Xiu Qin,Kurt Zatloukal,Lijian Hui,Erwin F. Wagner +12 more
TL;DR: A regulatory network connecting stress response and histone modification in liver tumour initiation, which could be targeted to prevent liver tumorigenesis is revealed.
Journal ArticleDOI
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Deobrat Dixit,Briana C. Prager,Briana C. Prager,Briana C. Prager,Ryan C. Gimple,Ryan C. Gimple,Hui Xian Poh,Yang Wang,Qiulian Wu,Zhixin Qiu,Reilly L. Kidwell,Leo J.Y. Kim,Leo J.Y. Kim,Qi Xie,Kristoffer Vitting-Seerup,Shruti Bhargava,Zhen Dong,Li Jiang,Zhe Zhu,Petra Hamerlik,Samie R. Jaffrey,Jing Crystal Zhao,Xiuxing Wang,Jeremy N. Rich,Jeremy N. Rich +24 more
TL;DR: YTHDF2 links RNA epitranscriptomic modifications and GSC growth, laying the foundation for the YTHDF 2-MYC-IGFBP3 axis as a specific and novel therapeutic target in glioblastoma.
Journal ArticleDOI
Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock
Zhen Dong,Guoxin Zhang,Meng Qu,Ryan C. Gimple,Ryan C. Gimple,Qiulian Wu,Zhixin Qiu,Briana C. Prager,Briana C. Prager,Xiuxing Wang,Leo J.Y. Kim,Leo J.Y. Kim,Andrew R. Morton,Deobrat Dixit,Wenchao Zhou,Haidong Huang,Bin Li,Zhe Zhu,Shideng Bao,Stephen C. Mack,Lukas Chavez,Steve A. Kay,Jeremy N. Rich +22 more
TL;DR: Collectively, GSCs coopt circadian regulators beyond canonical circadian circuitry to promote stemness maintenance and metabolism, offering novel therapeutic paradigms.
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Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions.
Min Tang,Qi Xie,Ryan C. Gimple,Ryan C. Gimple,Zheng Zhong,Trevor Tam,Jing Tian,Reilly L. Kidwell,Qiulian Wu,Briana C. Prager,Zhixin Qiu,Aaron Yu,Zhe Zhu,Pinar Mesci,Hui Jing,Jacob Schimelman,Pengrui Wang,Derrick Lee,Michael H. Lorenzini,Deobrat Dixit,Linjie Zhao,Shruti Bhargava,Tyler E. Miller,Xueyi Wan,Jing Tang,Bingjie Sun,Benjamin F. Cravatt,Alysson R. Muotri,Shaochen Chen,Jeremy N. Rich +29 more
TL;DR: A rapid three-dimensional bioprinting method to construct clinically relevant biomimetic tissue models that predictive of patient survival, maintenance of stemness, invasion, and drug resistance, and unique molecular dependencies in GSCs, relative to sphere culture are developed.
Journal ArticleDOI
A Pharmacogenomic Landscape in Human Liver Cancers
Zhixin Qiu,Hong Li,Zhengtao Zhang,Zhenfeng Zhu,Sheng He,Sheng He,Xujun Wang,Pengcheng Wang,Jianjie Qin,Liping Zhuang,Wei Wang,Xie Fubo,Ying Gu,Keke Zou,Chao Li,Chun Li,Chenhua Wang,Jin Cen,Xiaotao Chen,Yajing Shu,Zhao Zhang,Lulu Sun,Lihua Min,Yong Fu,Xiao-Wu Huang,Hui Lv,He Zhou,Yuan Ji,Zhigang Zhang,Zhiqiang Meng,Xiaolei Shi,Haibin Zhang,Yixue Li,Lijian Hui,Lijian Hui +34 more
TL;DR: The Liver Cancer Model Repository (LIMORE) as mentioned in this paper represented genomic and transcriptomic heterogeneity of primary liver cancers and provided a rich resource to facilitate drug discovery in liver cancers.