Jian Wang

TL;DR: It is demonstrated that self-reactivity, defined as “autoproliferation” of peripheral Th1 cells, is elevated in patients carrying the HLA-DR15 haplotype, and RASGRP2 is identified as target autoantigen that is expressed in the brain and B cells.

TL;DR: Both HLA-DR15 allomorphs jointly shape an autore active T cell repertoire by serving as antigen-presenting structures and epitope sources and by presenting the same foreign peptides and autoantigens to autoreactive CD4+ T cells in MS.

TL;DR: The HLA Ligand Atlas as discussed by the authors is a collection of paired HLAI and HLA-II immunopeptidomes from 227 benign human tissue samples, which facilitates a balanced comparison between tumor and benign tissues on HLA ligand level.

TL;DR: The HLA Ligand Atlas is described, a comprehensive collection of matched HLA class I and class II ligandomes from 29 non-malignant tissues and 13 human subjects, covering 38 HLAclass I, and 17 HLA*DRB alleles, nearly 50% of HLA ligands have not been previously described.