Wolfgang Faigle

TL;DR: It is found that both PrPc and PrPsc were actively released into the extracellular environment by PrP-expressing cells before and after infection with sheep prions, respectively, and exosomes bearing PrP sc are infectious.

TL;DR: It is demonstrated that self-reactivity, defined as “autoproliferation” of peripheral Th1 cells, is elevated in patients carrying the HLA-DR15 haplotype, and RASGRP2 is identified as target autoantigen that is expressed in the brain and B cells.

TL;DR: Analysis of major histocompatibility complex class II functions and intracellular transport in Epstein Barr Virus–transformed B cells from CHS patients suggests that the product of the Lyst gene is required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.

TL;DR: Engrailed is both a survival factor for adult mDA neurons and a regulator of their physiological activity, and the unilateral infusion of Engrailed into the midbrain increases striatal dopamine content, resulting in contralateral amphetamine-induced turning.

TL;DR: High performance and reproducibility for digesting recombinant human growth hormone are confirmed by analysing the digest products in both CE and MALDI-TOF MS.