J
Jiangming Sun
Researcher at Lund University
Publications - 47
Citations - 655
Jiangming Sun is an academic researcher from Lund University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 37 publications receiving 461 citations. Previous affiliations of Jiangming Sun include Tongji University & Max Planck Society.
Papers
More filters
Journal ArticleDOI
ExCAPE-DB: an integrated large scale dataset facilitating Big Data analysis in chemogenomics
Jiangming Sun,Nina Jeliazkova,Vladimir Chupakhin,Jose-Felipe Golib-Dzib,Ola Engkvist,Lars Carlsson,Jörg K. Wegner,Hugo Ceulemans,Ivan Georgiev,Vedrin Jeliazkov,Nikolay Kochev,Thomas J. Ashby,Hongming Chen +12 more
TL;DR: In this article, the authors compile a comprehensive chemogenomics dataset with over 70 million SAR data points from publicly available databases (PubChem and ChEMBL) including structure, target information and activity annotations.
Journal ArticleDOI
Applying Mondrian Cross-Conformal Prediction To Estimate Prediction Confidence on Large Imbalanced Bioactivity Data Sets
TL;DR: The results show that MCCP in general performed well on bioactivity data sets with various imbalance levels and not only provides confidence of prediction and prediction regions compared to standard machine learning methods but also produces valid predictions for the minority class.
Journal ArticleDOI
Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes
Vladimir V. Sharoyko,Mia Abels,Jiangming Sun,Lisa M. Nicholas,Inês G. Mollet,Jelena Stamenkovic,Isabel Göhring,Siri Malmgren,Petter Storm,João Fadista,Peter Spégel,Metodi D. Metodiev,Nils-Göran Larsson,Lena Eliasson,Nils Wierup,Hindrik Mulder +15 more
TL;DR: It is demonstrated that Tfb1m-deficiency in β-cells caused mitochondrial dysfunction and subsequently diabetes owing to combined loss of β-cell function and mass, the hallmarks of T2D.
Journal ArticleDOI
A novel structural position-specific scoring matrix for the prediction of protein secondary structures
TL;DR: For the first time a structural position-specific scoring matrix (SPSSM) is proposed, and an unprecedented database of 9 million sequences and their SPSSMs is established, providing a novel prediction tool: S PSSMPred.
Journal ArticleDOI
Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoA/ROCK signaling and disassembling glucotoxicity-induced stress fibers.
Xiangchen Kong,Dan Yan,Jiangming Sun,Xuerui Wu,Hindrik Mulder,Xianxin Hua,Xianxin Hua,Xiaosong Ma +7 more
TL;DR: A novel mechanism whereby GLP-1 potentiates glucotoxicity-diminished GSIS by depolymerizing F-actin cytoskeleton via protein kinase A-mediated inhibition of the RhoA-ROCK signaling pathway is unraveled.