M
Metodi D. Metodiev
Researcher at Paris Descartes University
Publications - 34
Citations - 2219
Metodi D. Metodiev is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Mitochondrial translation & Mitochondrial DNA. The author has an hindex of 18, co-authored 31 publications receiving 1839 citations. Previous affiliations of Metodi D. Metodiev include University of Paris & Necker-Enfants Malades Hospital.
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Journal ArticleDOI
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome.
Metodi D. Metodiev,Nicole Lesko,Chan Bae Park,Yolanda Cámara,Yonghong Shi,Rolf Wibom,Kjell Hultenby,Claes M. Gustafsson,Nils-Göran Larsson +8 more
TL;DR: The results thus show that TFB1M is a nonredundant dimethyltransferase in mammalian mitochondria and provide a possible explanation for the universal conservation of adenine dimethylation of rRNA by showing a critical role in ribosome maintenance.
Journal ArticleDOI
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs
Benedetta Ruzzenente,Benedetta Ruzzenente,Metodi D. Metodiev,Anna Wredenberg,Ana Bratic,Ana Bratic,Chan Bae Park,Yolanda Cámara,Dusanka Milenkovic,Volker Zickermann,Rolf Wibom,Kjell Hultenby,Hediye Erdjument-Bromage,Paul Tempst,Ulrich Brandt,James B. Stewart,Claes M. Gustafsson,Nils-Göran Larsson,Nils-Göran Larsson +18 more
TL;DR: It is shown here that the leucine‐rich pentatricopeptide repeat containing (LRPPRC) gene is essential for embryonic development and point to the existence of an elaborate machinery that regulates mammalian mtDNA expression at the post‐transcriptional level.
Journal ArticleDOI
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome
Yolanda Cámara,Jorge Asin-Cayuela,Chan Bae Park,Metodi D. Metodiev,Yonghong Shi,Yonghong Shi,Benedetta Ruzzenente,Christian Kukat,Bianca Habermann,Rolf Wibom,Kjell Hultenby,Thomas Franz,Hediye Erdjument-Bromage,Paul Tempst,B. Martin Hallberg,Claes M. Gustafsson,Nils-Göran Larsson,Nils-Göran Larsson +17 more
TL;DR: The results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria and directly controls mitochondrial ribosomal biogenesis and translation.
Journal ArticleDOI
NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly
Metodi D. Metodiev,Henrik Spåhr,Paola Loguercio Polosa,Caroline Meharg,Christian Becker,Janine Altmueller,Bianca Habermann,Nils-Goeran Larsson,Benedetta Ruzzenente +8 more
TL;DR: It is demonstrated that the m5C methyltransferase NSUN4, which forms a complex with MTERF4, is essential in mitochondrial ribosomal biogenesis as mitochondrial translation is abolished in conditional Nsun4 mouse knockouts.
Journal ArticleDOI
Variable and Tissue-Specific Subunit Composition of Mitochondrial m-AAA Protease Complexes Linked to Hereditary Spastic Paraplegia
TL;DR: It is proposed that the formation of m-AAA proteases with altered substrate specificities leads to axonal degeneration in hereditary spastic paraplegia (HSP), and homo-oligomeric Afg3l2 complexes accumulate, and these complexes can substitute for housekeeping functions of paraplegin-containing m- AAA complexes.