Jie Jiang

TL;DR: The isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates are demonstrated and an immune-dominant neutralizing epitope is identified which can be exploited for vaccine development.

TL;DR: Findings suggest that p495 particles produced in E. coli are ideal for the development of next-generation prophylactic vaccines against hepatitis E.

TL;DR: The neutralization mechanism of a potent nAb 8C11 against the hepatitis E virus (HEV), a nonenveloped positive-sense single-stranded RNA virus associated with abundant acute hepatitis is reported and a strategy to raise collision-inducing nAbs against single spike moieties that feature in the context of the entire pathogen at positions where the neighboring space cannot afford to accommodate an antibody is proposed.

TL;DR: The self-assembly of an engineered capsid protein built through artificial disulfide bonding (CA N21C/A22C) was found to self-assemble into particles in relatively high ionic solutions and the structure of one fraction of the globular particles was determined.

TL;DR: In this paper, the Pichia pastoris expression system was used to express the hemagglutinin-based recombinant subunit vaccine with rational design as a substitute for traditional virion-based vaccine development and achieved a high yield of about 120 mg/L through the use of fed-batch scalable fermentation.