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Lisheng Yang
Researcher at Xiamen University
Publications - 21
Citations - 438
Lisheng Yang is an academic researcher from Xiamen University. The author has contributed to research in topics: Epitope & Enterovirus 71. The author has an hindex of 12, co-authored 21 publications receiving 372 citations. Previous affiliations of Lisheng Yang include Enterprise Community Partners.
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Journal ArticleDOI
The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy chinese infants and children.
Qunying Mao,Tong Cheng,Fengcai Zhu,Jingxin Li,Yiping Wang,Yanping Li,Fan Gao,Lisheng Yang,Xin Yao,Jie Shao,Ningshao Xia,Zhenglun Liang,Junzhi Wang +12 more
TL;DR: The results demonstrated broad cross-neutralizing activity induced by two C4 EV71 vaccines in healthy Chinese infants and children, however, the degree of induced cross-protective immunity, and the potential escape evolution for EV71 still need to be monitored and researched in future.
Journal ArticleDOI
Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop.
Longfa Xu,Delei He,Zhiqun Li,Jun Zheng,Lisheng Yang,Miao Yu,Hai Yu,Yixin Chen,Yuqiong Que,James Wai-Kuo Shih,Gang Liu,Jun Zhang,Qinjian Zhao,Tong Cheng,Ningshao Xia +14 more
TL;DR: The results suggest that a broad-spectrum vaccine strategy targeting the high-affinity epitope of VP2 EF loop may elicits effective immune responses against EV71 infection.
Journal ArticleDOI
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody.
Longfa Xu,Qingbing Zheng,Shaowei Li,Maozhou He,Yangtao Wu,Yongchao Li,Rui Zhu,Hai Yu,Qiyang Hong,Jie Jiang,Zizhen Li,Shuxuan Li,Huan Zhao,Lisheng Yang,Wangheng Hou,Wei Wang,Xiangzhong Ye,Jun Zhang,Timothy S. Baker,Tong Cheng,Z. Hong Zhou,Z. Hong Zhou,Xiaodong Yan,Xiaodong Yan,Ningshao Xia +24 more
TL;DR: The isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates are demonstrated and an immune-dominant neutralizing epitope is identified which can be exploited for vaccine development.
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A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71
Longfa Xu,Delei He,Lisheng Yang,Zhiqun Li,Xiangzhong Ye,Hai Yu,Huan Zhao,Shuxuan Li,Lunzhi Yuan,Hongliu Qian,Yuqiong Que,James Wai-Kuo Shih,Hua Zhu,Yimin Li,Tong Cheng,Ningshao Xia +15 more
TL;DR: It is illustrated that the chimeric VLP HBc-E1/2 is a promising candidate for a broad-spectrum HFMD vaccine, and also reveals mechanisms of protection by the neighboring linear epitopes of the VP1 GH and VP2 EF loops.
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Analysis of cross-reactive neutralizing antibodies in human HFMD serum with an EV71 pseudovirus-based assay.
Huafei Zhang,Dong An,Wei Liu,Qunying Mao,Jun Jin,Lin Xu,Shiyang Sun,Liping Jiang,Xiaojun Li,Jie Shao,Hongxia Ma,Xueyong Huang,Shijie Guo,Haiying Chen,Tong Cheng,Lisheng Yang,Weiheng Su,Wei Kong,Zhenglun Liang,Chunlai Jiang +19 more
TL;DR: Antibodies induced by EV71-C4a were cross-reactive for different EV71 genotypes, demonstrating that C4a is a good candidate strain for an EV71 vaccine and that this new assay is practical for analyses of clinical samples from epidemiological and vaccine studies.