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Longfa Xu
Researcher at Xiamen University
Publications - 33
Citations - 454
Longfa Xu is an academic researcher from Xiamen University. The author has contributed to research in topics: Epitope & Neutralization. The author has an hindex of 12, co-authored 29 publications receiving 345 citations.
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Journal ArticleDOI
Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop.
Longfa Xu,Delei He,Zhiqun Li,Jun Zheng,Lisheng Yang,Miao Yu,Hai Yu,Yixin Chen,Yuqiong Que,James Wai-Kuo Shih,Gang Liu,Jun Zhang,Qinjian Zhao,Tong Cheng,Ningshao Xia +14 more
TL;DR: The results suggest that a broad-spectrum vaccine strategy targeting the high-affinity epitope of VP2 EF loop may elicits effective immune responses against EV71 infection.
Journal ArticleDOI
Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody.
Longfa Xu,Qingbing Zheng,Shaowei Li,Maozhou He,Yangtao Wu,Yongchao Li,Rui Zhu,Hai Yu,Qiyang Hong,Jie Jiang,Zizhen Li,Shuxuan Li,Huan Zhao,Lisheng Yang,Wangheng Hou,Wei Wang,Xiangzhong Ye,Jun Zhang,Timothy S. Baker,Tong Cheng,Z. Hong Zhou,Z. Hong Zhou,Xiaodong Yan,Xiaodong Yan,Ningshao Xia +24 more
TL;DR: The isolation of two forms of stable CVA6 particles-procapsid and A-particle-with excellent biochemical stability and natural antigenicity to serve as vaccine candidates are demonstrated and an immune-dominant neutralizing epitope is identified which can be exploited for vaccine development.
Journal ArticleDOI
A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71
Longfa Xu,Delei He,Lisheng Yang,Zhiqun Li,Xiangzhong Ye,Hai Yu,Huan Zhao,Shuxuan Li,Lunzhi Yuan,Hongliu Qian,Yuqiong Que,James Wai-Kuo Shih,Hua Zhu,Yimin Li,Tong Cheng,Ningshao Xia +15 more
TL;DR: It is illustrated that the chimeric VLP HBc-E1/2 is a promising candidate for a broad-spectrum HFMD vaccine, and also reveals mechanisms of protection by the neighboring linear epitopes of the VP1 GH and VP2 EF loops.
ComponentDOI
Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Qingbing Zheng,Rui Zhu,Longfa Xu,Maozhou He,X. Yan,X. Yan,Dongxiao Liu,Zhichao Yin,Y. Wu,Y. Li,L. Yang,W. Hou,Shaowei Li,Z. Li,Zhenqin Chen,Hai Yu,Y. Gu,Jun Zhang,Timothy S. Baker,Z.H. Zhou,Barney S. Graham,Tong Cheng,Ningshao Xia +22 more
TL;DR: The structures of three EV-D68 capsid states representing the virus at major phases are reported and two original monoclonal antibodies are described with distinct structurally defined mechanisms for virus neutralization.
Journal ArticleDOI
Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.
Rui Zhu,Tong Cheng,Zhichao Yin,Dongxiao Liu,Longfa Xu,Yongchao Li,Wei Wang,Jian Liu,Yuqiong Que,Xiangzhong Ye,Qiyi Tang,Qinjian Zhao,Shengxiang Ge,Shuizhen He,Ningshao Xia +14 more
TL;DR: This is the first report detailing the seroepidemiology of eight prevalent EVs in the same population, which provides scientific data supporting further studies on the improvement of EV-related disease prevention and control.