S
Siva Sundara Kumar Durairajan
Researcher at Central University of Tamil Nadu
Publications - 58
Citations - 1976
Siva Sundara Kumar Durairajan is an academic researcher from Central University of Tamil Nadu. The author has contributed to research in topics: Autophagy & Amyloid precursor protein. The author has an hindex of 19, co-authored 53 publications receiving 1545 citations. Previous affiliations of Siva Sundara Kumar Durairajan include Hong Kong Baptist University & Central University, India.
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Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model
Siva Sundara Kumar Durairajan,Liang-Feng Liu,Jia-Hong Lu,Lei-Lei Chen,Qiuju Yuan,Sookja K. Chung,Ling Huang,Xing-Shu Li,Jian-Dong Huang,Min Li +9 more
TL;DR: The results suggest that BBR provides neuroprotective effects in TgCRND8 mice through regulating APP processing and that further investigation of the BBR for therapeutic use in treating AD is warranted.
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Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation
Jia-Hong Lu,Mustafa T. Ardah,Siva Sundara Kumar Durairajan,Liang-Feng Liu,Li-Xia Xie,Wang-Fun Fong,Mohamed Y. Hasan,Jian-Dong Huang,Omar M. A. El-Agnaf,Min Li +9 more
TL;DR: Zhang et al. as discussed by the authors showed that Baicalein, a flavonoid extracted from the Chinese herbal medicine Scutellaria baicalensis Georgi ("huang qin" in Chinese), is a potent inhibitor of α-syn oligomerization both in cell-free and cellular systems.
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Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.
Jia-Hong Lu,Jieqiong Tan,Siva Sundara Kumar Durairajan,Liang-Feng Liu,Zhuohua Zhang,Long Ma,Han-Ming Shen,H. Y.Edwin Chan,Min Li +8 more
TL;DR: Data from this study raise the possibility that oxindole alkaloid derivatives may serve as a means to stimulate autophagy in neuronal cells, thereby exerting preventive and therapeutic values against neurodegenerative diseases such as Parkinson disease by reducing pathogenic protein aggregates in neurons.
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Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty
Siva Sundara Kumar Durairajan,Qiuju Yuan,Li-Xia Xie,Wing Sai Chan,Wan Fung Kum,Irene Koo,Chenli Liu,You-Qiang Song,Jian-Dong Huang,William L. Klein,Min Li +10 more
TL;DR: Sal B is a better aggregation inhibitor than ferulic acid but less active than curcumin in the inhibition of Aβ1–40 aggregation, and has therapeutic potential in the treatment of AD, and warrants its study in animal models.
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A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
Ju-Xian Song,Yueru Sun,Ivana Peluso,Yu Zeng,Xing Yu,Jia-Hong Lu,Zheng Xu,Mingzhong Wang,Liang-Feng Liu,Yingyu Huang,Lei-Lei Chen,Siva Sundara Kumar Durairajan,Hongjie Zhang,Bo Zhou,Hong Qi Zhang,Aiping Lu,Andrea Ballabio,Diego L. Medina,Zhihong Guo,Min Li +19 more
TL;DR: Curcumin derivative C1 is identified as a novel MTOR-independent activator of TFEB, which enhances autophagy and lysosome biogenesis in vitro and in vivo and is a potential therapeutic agent for the treatment of neurodegenerative diseases.