Liang Xue

TL;DR: In this article, the authors used quantitative phosphoproteomics to compare the global changes in phosphopeptides in WT and snrk2.2.3/2.6 triple mutant seedlings.

TL;DR: A general strategy to isolate and identify phosphoproteins in extracellular vesicles from human plasma as potential markers to differentiate disease from healthy states is presented and may transform cancer screening and monitoring.

TL;DR: It is demonstrated that BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a mitochondrial BH3-only protein, interacts with PINK1 to promote the accumulation of full-length Pink1 on the outer membrane of mitochondria, which facilitates parkin recruitment and PINK 1/parkin-mediated mitophagy.

TL;DR: The results demonstrate an important role of basal ABA signaling in growth, senescence, and abscission and reveal that PYLs antagonize ABA-independent activation of SnRK2s by osmotic stress.

TL;DR: An integrated proteomic strategy that combines a sensitive kinase reaction with endogenous kinase-dependent phosphoproteomics to identify direct substrates of protein kinases is described, supporting a unique mechanism that Syk negatively affects cell division through its centrosomal kinase activity.