Liang-Feng Liu

TL;DR: The results suggest that BBR provides neuroprotective effects in TgCRND8 mice through regulating APP processing and that further investigation of the BBR for therapeutic use in treating AD is warranted.

TL;DR: Zhang et al. as discussed by the authors showed that Baicalein, a flavonoid extracted from the Chinese herbal medicine Scutellaria baicalensis Georgi ("huang qin" in Chinese), is a potent inhibitor of α-syn oligomerization both in cell-free and cellular systems.

TL;DR: Data from this study raise the possibility that oxindole alkaloid derivatives may serve as a means to stimulate autophagy in neuronal cells, thereby exerting preventive and therapeutic values against neurodegenerative diseases such as Parkinson disease by reducing pathogenic protein aggregates in neurons.

TL;DR: Curcumin derivative C1 is identified as a novel MTOR-independent activator of TFEB, which enhances autophagy and lysosome biogenesis in vitro and in vivo and is a potential therapeutic agent for the treatment of neurodegenerative diseases.

TL;DR: In this article, SNCA/α-synuclein and its rare mutations are considered as the culprit proteins in Parkinson disease (PD), and the dynamic changes in autophagy process and confirmed that overexpression of both WT and SNCAA53T inhibits autophagia in PC12 cells in a time-dependent manner.