J
Jin Huang
Researcher at East China University of Science and Technology
Publications - 121
Citations - 3279
Jin Huang is an academic researcher from East China University of Science and Technology. The author has contributed to research in topics: Virtual screening & Dihydroorotate dehydrogenase. The author has an hindex of 26, co-authored 114 publications receiving 2533 citations.
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Journal ArticleDOI
Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference
Feixiong Cheng,Chuang Liu,Jing Jiang,Weiqiang Lu,Weihua Li,Guixia Liu,Wei-Xing Zhou,Jin Huang,Yun Tang +8 more
TL;DR: Three supervised inference methods were developed here to predict DTI and used for drug repositioning and indicated that these methods could be powerful tools in prediction of DTIs and drugRepositioning.
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Target identification among known drugs by deep learning from heterogeneous networks.
Xiangxiang Zeng,Siyi Zhu,Weiqiang Lu,Zehui Liu,Jin Huang,Yadi Zhou,Jiansong Fang,Yin Huang,Yin Huang,Huimin Guo,Lang Li,Bruce D. Trapp,Ruth Nussinov,Ruth Nussinov,Charis Eng,Joseph Loscalzo,Feixiong Cheng,Feixiong Cheng,Feixiong Cheng +18 more
TL;DR: DeepDTnet offers a powerful network-based deep learning methodology for target identification to accelerate drug repurposing and minimize the translational gap in drug development.
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A genome-wide positioning systems network algorithm for in silico drug repurposing.
Feixiong Cheng,Weiqiang Lu,Chuang Liu,Jiansong Fang,Yuan Hou,Diane E. Handy,Rui-Sheng Wang,Yuzheng Zhao,Yi Yang,Jin Huang,David E. Hill,Marc Vidal,Charis Eng,Joseph Loscalzo +13 more
TL;DR: A network-based methodology to identify individualized disease modules by mapping patients’ DNA and RNA sequencing profiles to the interactome, enabling prediction of cancer type-specific drug responses and prediction of drug responses is introduced.
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Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
Shuaishuai Ni,Yaxia Yuan,Jin Huang,Xiaona Mao,Maosheng Lv,Jin Zhu,Xu Shen,Xu Shen,Jianfeng Pei,Luhua Lai,Hualiang Jiang,Hualiang Jiang,Jian Li +12 more
TL;DR: This work describes an integrated approach of de novo drug design, chemical synthesis, and bioassay for quick identification of a series of novel small molecule cyclophilin A (CypA) inhibitors (1-3).
Journal ArticleDOI
Comprehensive characterization of protein–protein interactions perturbed by disease mutations
Feixiong Cheng,Junfei Zhao,Yang Wang,Weiqiang Lu,Zehui Liu,Yadi Zhou,William R. Martin,Rui-Sheng Wang,Jin Huang,Tong Hao,Hong Yue,Jing Ma,Yuan Hou,Jessica A. Castrillon,Jiansong Fang,Jiansong Fang,Justin D. Lathia,Ruth A. Keri,Felice C. Lightstone,Elliott M. Antman,Raul Rabadan,David E. Hill,Charis Eng,Marc Vidal,Joseph Loscalzo +24 more
TL;DR: This human interactome network framework provides a powerful tool for prioritization of alleles with PPI-perturbing mutations to inform pathobiological mechanism- and genotype-based therapeutic discovery.