J
Jin Zhong
Researcher at Chinese Academy of Sciences
Publications - 172
Citations - 7453
Jin Zhong is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 34, co-authored 149 publications receiving 6352 citations. Previous affiliations of Jin Zhong include Scripps Research Institute & ShanghaiTech University.
Papers
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Journal ArticleDOI
Robust hepatitis C virus infection in vitro
Jin Zhong,Pablo Gastaminza,Guofeng Cheng,Sharookh B. Kapadia,Takanobu Kato,Dennis R. Burton,Stefan Wieland,Susan L. Uprichard,Takaji Wakita,Francis V. Chisari +9 more
TL;DR: A simple yet robust HCV cell culture infection system based on the HCV JFH-1 molecular clone and Huh-7-derived cell lines that allows the production of virus that can be efficiently propagated in tissue culture is reported.
Journal ArticleDOI
Cellular Determinants of Hepatitis C Virus Assembly, Maturation, Degradation, and Secretion
TL;DR: The results suggest that by coopting the VLDL assembly, maturation, degradation, and secretory machinery of the cell, HCV acquires its hepatocyte tropism and, by mimicry, its tendency to persist.
Journal ArticleDOI
Persistent hepatitis C virus infection in vitro: coevolution of virus and host.
Jin Zhong,Pablo Gastaminza,Josan Chung,Zania Stamataki,Masanori Isogawa,Guofeng Cheng,Jane A. McKeating,Francis V. Chisari +7 more
TL;DR: The establishment and the characteristics of persistent in vitro infection of human hepatoma-derived cells by a recently described HCV genotype 2a infectious molecular clone reveal the existence of coevolutionary events during persistent HCV infection that favor survival of both virus and host.
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Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria
TL;DR: It is shown that retargeted group II introns can be used for highly specific chromosomal gene disruption in Escherichia coli and other bacteria at frequencies of 0.1–22%.
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Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies
Joe Grove,Søren Nielsen,Jin Zhong,Margaret F. Bassendine,Heidi E. Drummer,Peter Balfe,Jane A. McKeating +6 more
TL;DR: Mutation of E2 at position 451 alters the relationship between particle density and infectivity, disrupts coreceptor dependence, and increases virion sensitivity to receptor mimics and NAbs, suggesting the evasion of host immune responses.