J
Jindong Chen
Researcher at University of Rochester Medical Center
Publications - 37
Citations - 2762
Jindong Chen is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Folliculin & Thalassemia. The author has an hindex of 20, co-authored 34 publications receiving 2570 citations. Previous affiliations of Jindong Chen include Zunyi Medical College & Van Andel Institute.
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Journal ArticleDOI
HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome
John D. Carpten,Christiane M. Robbins,Andrea Villablanca,Lars Forsberg,Silvano Presciuttini,Joan E. Bailey-Wilson,William F. Simonds,E. Gillanders,A.M. Kennedy,Jindong Chen,Sunita K. Agarwal,Raman Sood,Mary Pat Jones,Tracy Moses,C. Haven,David Petillo,P.D. Leotlela,Brian Harding,David Cameron,Anna A.J. Pannett,Anders Höög,H. Heath,Laura James-Newton,Bruce G. Robinson,R.J. Zarbo,Branca M. Cavaco,Wassif S. Wassif,N.D. Perrier,I.B. Rosen,Ulf Kristoffersson,Peter D. Turnpenny,Lars-Ove Farnebo,G. M. Besser,Charles E. Jackson,Hans Morreau,J.M. Trent,Rajesh V. Thakker,Stephen J. Marx,Bin Tean Teh,Catharina Larsson,Maurine R. Hobbs +40 more
TL;DR: The findings suggest that HRPT2 is a tumor-suppressor gene, the inactivation of which is directly involved in predisposition to HPT–JT and in development of some sporadic parathyroid tumors.
Journal ArticleDOI
HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours
Viive M. Howell,Carola J. Haven,K. Kahnoski,Sok Kean Khoo,David Petillo,Jindong Chen,Gert Jan Fleuren,Bruce G. Robinson,Leigh Delbridge,Jeanette Philips,Anne E. Nelson,Ulf Krause,K. Hammje,Henning Dralle,Cuong Hoang-Vu,Oliver Gimm,Deborah J. Marsh,Hans Morreau,Bin Tean Teh +18 more
TL;DR: The results in this study support the role of HRPT2 as a tumour suppressor gene in sporadic parathyroid carcinoma, and provide further evidence for HRPT 2 as the causative gene in HPT-JT, and a subset of FIHP.
Journal ArticleDOI
Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells.
Chao Nan Qian,Bree Berghuis,Galia Tsarfaty,Mary Beth Bruch,Eric J. Kort,Jon Ditlev,Ilan Tsarfaty,Eric Hudson,David A. Jackson,David Petillo,Jindong Chen,James H. Resau,Bin Tean Teh +12 more
TL;DR: The hypothesis that modification of the microenvironment for a secondary tumor can be initiated by a primary tumor before and independent of the physical presence of metastatic cancer cells is supported.
Journal Article
Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma.
Chao-Nan Qian,Xiang Guo,Brian Cao,Eric J. Kort,Chong-Chou Lee,Jindong Chen,Ling-Mei Wang,W. Mai,Hua-Qing Min,Ming-Huang Hong,George F. Vande Woude,James H. Resau,Bin Tean Teh +12 more
TL;DR: High Met protein expression level correlates with poorer survival in late-stage NPC and serves as an independent prognostic indicator; and the Met receptor in NPC is activated by its paracrine ligand HGF from the interstitial tissues rather than by an autocrine loop or its activating mutation.
Journal ArticleDOI
Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinoma
Kyle A. Furge,Jindong Chen,Julie Koeman,Pamela J. Swiatek,Karl Dykema,Kseniji Lucin,Richard J. Kahnoski,Ximing J. Yang,Bin Tean Teh,Bin Tean Teh +9 more
TL;DR: Computational and genetic evidence is provided that activation of Myc is associated with the aggressiveness of papillary type 2 RCC and it will be useful to consider inhibition of components of the MYC signaling pathway as avenues for therapeutic intervention in high-grade papillary RCC.