J
Jing Shan
Researcher at Massachusetts Institute of Technology
Publications - 16
Citations - 929
Jing Shan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: High-content screening & Osteoblast. The author has an hindex of 9, co-authored 16 publications receiving 851 citations. Previous affiliations of Jing Shan include Columbia University.
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Journal ArticleDOI
Identification of small molecules for human hepatocyte expansion and iPS differentiation
Jing Shan,Robert E. Schwartz,Robert E. Schwartz,Nathan T. Ross,David J. Logan,David Thomas,Stephen A. Duncan,Trista E. North,Trista E. North,Wolfram Goessling,Wolfram Goessling,Anne E. Carpenter,Sangeeta N. Bhatia +12 more
TL;DR: In this paper, the authors developed a high-throughput screening platform for primary human hepatocytes to identify small molecules in two different classes that can be used to generate renewable sources of functional human hepatocyte.
Identification of small molecules for human hepatocyte expansion and iPS differentiation
Jing Shan,Nathan T. Ross,David J. Logan,David Thomas,Stephen A. Duncan,Trista E. North,Wolfram Goessling,Anne E. Carpenter,Robert E. Schwartz,Sangeeta N. Bhatia +9 more
TL;DR: A high-throughput screening platform for primary human hepatocytes is developed to identify small molecules in two different classes that can be used to generate renewable sources of functional human liver cells in vitro.
Journal ArticleDOI
A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax
Sandra March,Shengyong Ng,Soundarapandian Velmurugan,Ani Galstian,Ani Galstian,Jing Shan,David J. Logan,Anne E. Carpenter,David Thomas,B. Kim Lee Sim,Maria M. Mota,Stephen L. Hoffman,Sangeeta N. Bhatia +12 more
TL;DR: In this paper, the liver stages for both Plasmodium falciparum and PlasModium vivax were established in a micro-scale human liver platform composed of cryopreserved, micropatterned human primary hepatocytes surrounded by supportive stromal cells.
Journal ArticleDOI
Role of osteoblast-fibroblast interactions in the formation of the ligament-to-bone interface.
I-Ning E. Wang,Jing Shan,Rene Choi,Seongcheol Oh,Christopher K. Kepler,Faye H. Chen,Helen H. Lu +6 more
TL;DR: It is suggested that osteoblast–fibroblast interactions may lead to cell trans‐differentiation and eventual fibrocartilage formation, which are critical for interface tissue engineering and achieving biological fixation of soft tissue grafts to bone.
Journal ArticleDOI
Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro
Shengyong Ng,Robert E. Schwartz,Sandra March,Ani Galstian,Ani Galstian,Nil Gural,Jing Shan,Mythili Prabhu,Maria M. Mota,Sangeeta N. Bhatia +9 more
TL;DR: In vitro liver-stage malaria infections in iHLCs are established and differentiating cells acquire permissiveness to malaria infection at the hepatoblast stage and it is demonstrated that chemical maturation of iH LCs can improve their potential for antimalarial drug testing applications.